Nearly half of patients with high-grade, localized soft tissue sarcoma (STS) of extremities
and trunk wall develop disease recurrence after local therapy. Adjuvant chemotherapy with
ifosfamide and doxorubicin may improve long-term disease-free survival, but the benefit of
adjuvant treatment is limited and predictive factors for treatment response are lacking. The
aim of this study is to explore sequential treatment with ifosfamide and doxorubicin in a
neoadjuvant setting and to investigate biomarkers predictive of treatment response.
Connective and Soft Tissue Neoplasm,
All Solid Tumors,
Soft Tissue Sarcoma,
soft tissue sarcomas
If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.
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