The Belgian Diabetes in Pregnancy Follow-up Study

  • STATUS
    Recruiting
  • End date
    Jun 9, 2023
  • participants needed
    750
  • sponsor
    Universitaire Ziekenhuizen Leuven
Updated on 9 October 2021
diabetes
oral glucose tolerance test
fats

Summary

Gestational diabetes (GDM) is a form of diabetes that develops during pregnancy. GDM is associated with increased risks for pregnancy complications such as macrosomia s and preterm delivery. Women with a history of GDM have a high risk to develop a type 2 diabetes (T2DM) within the next ten years after delivery. The children are also at increased risk of developing obesity and T2DM later in life. Studies are needed to find more accurate predictors for the metabolic risk later in life. This will help to individualize the follow-up and to develop tailored prevention strategies in women and offspring with a history of GDM. In this research project we will therefore investigate how the long-term metabolic risk can more accurately be predicted in a follow-up cohort of the 'Belgian Diabetes in Pregnancy study' (BEDIP-N). We will study the relationship between maternal weight, degree of body fat and degree of hyperglycaemia in pregnancy on the long-term metabolic risk of 375 women and offspring pairs 3-7 years after the delivery across different gestational glucose tolerance groups based on the 2013 WHO criteria in pregnancy. In addition, we will study whether a promising new biomarker, glycated CD59, is a good predictor for the long-term metabolic risk.

Details
Condition Gestational Diabetes, Diabetes Mellitus, adiposity, Obesity, Pregnancy Complications, Diabetes Prevention, Diabetes Mellitus Types I and II, Type2 Diabetes, Diabetes (Pediatric)
Treatment GDM
Clinical Study IdentifierNCT04429958
SponsorUniversitaire Ziekenhuizen Leuven
Last Modified on9 October 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Mothers who participated in the completed BEDIP-N study and received both the GCT as the OGTT during pregnancy
Offspring born at the time of participation in the BEDIP-N study

Exclusion Criteria

Mothers
Current pregnancy
Treatment that influences glycaemic status such as high dose corticoids
History of bariatric surgery
gastro-intestinal surgery changing the absorption of glucose (Billroth II)
A normal study visit will not be possible (incompliance, psychiatric problems)
Diagnosed with type 1 diabetes or the presence of auto-immune antibodies for type 1 diabetes
Offspring
Treatment that influences glycaemic status such as high dose corticoids
A normal study visit will not be possible (incompliance, psychiatric problems)
Diagnosed with type 1 diabetes or the presence of auto-immune antibodies for type 1 diabetes
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