Pharmacogenetic Supported Prescribing in Kids

  • STATUS
    Recruiting
  • End date
    Jul 1, 2025
  • participants needed
    6000
  • sponsor
    University of Calgary
Updated on 23 March 2021

Summary

Implementation of pharmacogenetic testing for children and adolescents aged 7-17 who are starting or changing psychiatric medication.

Description

Children with moderate to severe mental health conditions (e.g. depression, anxiety, OCD) or neurodevelopmental disorders (e.g., autism spectrum disorders, ADHD) are frequently prescribed medications as either the sole form of treatment or in combination with psychotherapy. However, up to 50% of these children will not respond or experience burdensome adverse drug reactions to these medications. Current use of mental health-related medications (e.g., antidepressants, antipsychotics) in children can be best described as a trial-and-error process that can impact the well-being of those taking the medications and their families at a considerable economic cost. However, this trial-and-error process could, in part, be avoided through the application of pharmacogenetic testing, a specific type of genetic testing that has the potential to improve drug efficacy and reduce the morbidity, mortality and cost associated with adverse drug reactions. The aim of this project is to implement and evaluate an evidence-based pharmacogenetic testing service to improve drug treatment outcomes in children receiving mental health care.

Our objectives are to:

  1. Implement Canada's first pharmacogenetics testing service to improve drug treatment outcomes in children receiving mental health care.
  2. Collect performance, outcome, and economic indicators related to the pharmacogenetics testing service.
  3. Establish a research platform for the discovery of new genetic and non-genetic markers of drug treatment outcomes relevant to mental health care in children.

Details
Condition Mental Health Impairment
Treatment Pharmacogenetic testing
Clinical Study IdentifierNCT04797364
SponsorUniversity of Calgary
Last Modified on23 March 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Medical records available
The initiation, change, dose adjustment, or augmentation of psychiatric medication(s) is indicated
Treating psychiatrist, family physician, or pediatrician licensed in Alberta requests pharmacogenetic testing

Exclusion Criteria

Medically unstable or lacking capacity to provided informed consent
Unwillingness of child to provide saliva sample for genetic analysis
History of liver or bone marrow (hematopoietic cell) transplant
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact

site

0/250

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider

Loading...

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 

 • 

Private

Reply by • Private
Loading...

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.
Loading...

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note