Evaluation of the Effects of Immune Cells on Periodontal Healing (EMTA)

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    Biruni University
Updated on 23 March 2022
cell counts
periodontal treatment
severe periodontal disease


Periodontitis is an inflammatory disease with an infectious character, where, as the result of the host response to a dysbiotic microflora, attachment and bone loss occur. The host response and the healing period following the treatment differs among individuals, but the reason behind is not fully understood. The macrophages and T cells play an important role in the immune response and in the pathogenesis of periodontal diseases, but their role in the healing following periodontal therapy is not known. In this study, we aim to reveal the effects of initial macrophage and T cell activities in the gingival tissue on the differences of the response to phase I periodontal treatment.

42 individuals will be included in the study. Granulation tissue samples will be collected from two separate deep pockets of each individual, initially. At the same session, full-mouth scaling and root debridement will be conducted. Saliva, subgingival biofilm and gingival crevicular fluid (GCF) samples will also be collected, initially, and at the 2nd, 6th, 12th and 24th weeks. At the same appointments, periodontal parameters will be recorded. When the clinical procedures are concluded, the samples will be sent to Turku University with dry ice. Tissue and GCF concentrations of related cytokines will be analyzed with Luminex. The density of macrophage types will be defined by immunoblot analysis of related markers. Macrophage subpopulations in tissues will be specified by proteomics. Likewise, quantities of periodontal pathogens will be evaluated with DNA isolation and next generation sequencing.

Condition Periodontitis
Treatment Initial periodontal treatment
Clinical Study IdentifierNCT04792372
SponsorBiruni University
Last Modified on23 March 2022


Yes No Not Sure

Inclusion Criteria

moderate to severe periodontitis
having at least two pockets ≥ 6 mm
systemic healthy

Exclusion Criteria

received periodontal treatment prior to study
received antibiotic or antiinflammatory drugs in the last 6 months
pregnant or in lactation
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