Computerized Tests of Cognitive Decline in Presymptomatic Alzheimer's Disease

  • End date
    Oct 31, 2024
  • participants needed
  • sponsor
    Neurobehavioral Systems, Inc.
Updated on 24 January 2022
alzheimer's disease
cognitive decline
cognitive assessment
Accepts healthy volunteers


The investigators will study performance on computerized cognitive tasks in healthy participants of different ages to gather normative data for newly developed computerized cognitive tests. These tests are designed to permit the early detection of individuals at risk of age-related cognitive decline.


In Group A, the investigators will evaluate the performance of healthy older participants (N

  • 500, age range 60 to 89 years) for three days at enrollment and then at 6-month intervals for three years thereafter. The goal is to characterize changes in performance to aging and task experience in a group of older subjects. Subjects will also undergo APOE genetic testing with saliva samples.

In Group B, the investigators will compare the performance of normal participants (N = 100, age range 18 to 89) on computerized and manually administered cognitive tasks.

In Group C, the investigators will gather normative data from younger participants (N = 400, ages 18 to 59) for three days at enrollment. A subset of these subjects (N=150) will undergo longitudinal testing at 6-month intervals for three years thereafter.

In Group D, the investigators will examine the performance of participants (N=1000, ages 18 to 89) on a 30-min computerized cognitive screening test.

Condition Alzheimer Disease, Cognitive Decline, Aging
Treatment California Cognitive Assessment Battery, Fast Automated Cognitive Test Battery
Clinical Study IdentifierNCT04800588
SponsorNeurobehavioral Systems, Inc.
Last Modified on24 January 2022


Yes No Not Sure

Inclusion Criteria

Must be able to use computer mouse and touch screen
Must speak English as a primary language

Exclusion Criteria

History of psychiatric disorder
History of stroke or transient ischemic attack
History of substance abuse
History of medical or sensory disorders that are incompatible with effective testing
History of traumatic brain injury with hospitalization and extended loss of consciousness
History of epilepsy
History of depression or anxiety
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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