Severe Acute Respiratory Infection - Preparedness (COVID-19 and Influenza)

  • STATUS
    Recruiting
  • days left to enroll
    56
  • participants needed
    1200
  • sponsor
    University of Washington
Updated on 21 March 2021

Summary

Severe Acute Respiratory Infection (SARI) is defined by the World Health Organization (WHO) as acute respiratory infection with a history of fever 38C and cough for less than 10 days duration that requires hospital admission. SARI-PREP is a multi-center consortium funded by the CDC Foundation being assembled with the goal of providing the infrastructure to rapidly collect prospective data on clinical risks and outcomes, hospital-level stress, and biologic specimens that will aid in the rapid development of diagnostic and treatment approaches. A current example of a form of SARI to be targeted by SARI-PREP is COVID-19 the acute respiratory infectious disease caused by SARS-CoV-2 infection. COVID-19 has a broad set of manifestations and severity with a subset of affected patients developing severe disease leading to respiratory failure and other forms of organ dysfunction. As with many outbreaks of novel viral pathogens causing SARI there was no efficacious therapeutic intervention at the beginning of the COVID-19 pandemic. Furthermore, while there is emerging knowledge of clinical risks for severe COVID-19, there remains a paucity of information about the viral dynamics and host responses that might indicate a patient is at high risk for poor outcomes.

The COVID-19 pandemic will be the initial target of the SARI-PREP consortium with the overall goal of developing a multi-institutional collaborative network of Acute Care Hospitals that will rapidly enroll, sample, and follow patients admitted with severe COVID-19 and to develop research protocols to rapidly determine demographic, clinical, host molecular, virologic, and institutional correlates of outcome. Overall, the information gained from this effort will help to rapidly inform and improve clinical management of epidemic/pandemic SARI patients.

Details
Condition Viral pneumonia
Clinical Study IdentifierNCT04786301
SponsorUniversity of Washington
Last Modified on21 March 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Admission to an acute care or intensive care unit with a clinical syndrome of lower respiratory tract infection suspicious for viral SARI
fever
cough
AND (radiographic infiltrates by imaging (chest x-ray, CT scan, etc.) OR SpO2 94% on room air OR requiring new supplemental oxygen (above baseline if preexisting) OR requiring invasive or non-invasive mechanical ventilation)
confirmed viral cause for SARI by respiratory viral RT-PCR testing

Exclusion Criteria

Prisoners or wards of the state
Inability to consent or lack of availability of legal surrogate
Do not attempt resuscitation/do not intubate status on admission
Clear my responses

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