LD-FUD for Highly Aggressive Gastric Cancer

  • STATUS
    Recruiting
  • End date
    Oct 27, 2022
  • participants needed
    46
  • sponsor
    Sixth Affiliated Hospital, Sun Yat-sen University
Updated on 27 July 2021
ct scan
cancer
fluorouracil
metastasis
gastric adenocarcinoma
docetaxel
adenocarcinoma

Summary

A subtype of gastric adenocarcinoma with extensive bone marrow metastasis and DIC has been described. Few patients have been treated properly due to the lack of clinical trials. We designed this phase II study to explore a feasible regimen for this kind of highly aggressive gastric cancer.

Description

5-fluorouracil 200mg/m2/day continuously for 20 days; Docetaxel 25mg/m2, days 1, 8 and 15; This regimen repeats every 4 weeks.

Details
Condition Disseminated Intravascular Coagulation, Thrombocytopenia, Gastropathy, Gastric Cancer, Stomach Discomfort, Gastric Carcinoma, Thrombocytopenia and Thrombocytopenia Prevention, Stomach Cancer, gastric cancers, Bone Marrow Metastasis
Treatment docetaxel, 5-fluorouracil
Clinical Study IdentifierNCT04547153
SponsorSixth Affiliated Hospital, Sun Yat-sen University
Last Modified on27 July 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Pathologically confirmed gastric adenocarcinoma
Bone marrow metastasis confirmed by aspiration, biopsy or PET/CT scan
DIC
Sufficient liver and renal functions

Exclusion Criteria

treated by cytotoxic or target or I-O drugs
insufficient cardiac or pulmonary function
active infection
no contraceptive measures
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