Optimal Dosing For Low-Dose Aspirin Chemoprophylaxis For VTE Following Total Joint Arthroplasty

  • End date
    May 1, 2023
  • participants needed
  • sponsor
    University of Miami
Updated on 20 April 2022
total knee replacement
blood clot


This research study is attempting to answer the question of whether 81 mg aspirin once daily is as effective as 81 mg aspirin twice daily in preventing blood clots after total joint replacement surgery.

Condition Venous Thromboembolism
Treatment Aspirin
Clinical Study IdentifierNCT04295486
SponsorUniversity of Miami
Last Modified on20 April 2022


Yes No Not Sure

Inclusion Criteria

> 18 years of age
Planning to undergo a primary total hip or knee arthroplasty

Exclusion Criteria

High risk patients for VTE as defined by
History of venous thromboembolism
Active malignancy
Known pro thrombotic condition
BMI > 40
Patients requiring anticoagulation for pre-existing conditions
Patients with the contraindication for use of aspirin or nonsteroidal antiinflammatory drugs for reasons such as peptic ulcer disease, intolerance, others
Patients not fluent in the language of the informed consent form
Reported to have mental illness or belonging to a vulnerable population
Clear my responses

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What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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