Thumb Osteoarthritis Mechanisms

  • End date
    Jul 13, 2022
  • participants needed
  • sponsor
    University of Florida
Updated on 13 March 2021


This study examines carpometacarpal osteoarthritis (CMC OA) and aims to elucidate the biomechanical, neuromuscular, and somatosensory mechanisms that contribute to CMC OA symptoms by using orthopaedic biomechanics and quantitative pain testing. Completion of this study will provide a comprehensive dataset describing how movement strategies (muscle activity and joint posture) as well as experimental and clinical pain differ between individuals with CMC OA and age-matched controls.

Condition Carpometacarpal Osteoarthritis
Treatment Range of Motion Tasks, Strength Tasks
Clinical Study IdentifierNCT04104477
SponsorUniversity of Florida
Last Modified on13 March 2021


Yes No Not Sure

Inclusion Criteria

CMC OA Subjects
female between the age of 40 to 90 years
end-stage CMC OA diagnosed by a board-certified clinician
Age-Matched Control
female between the age of 40 to 90 years
no joint or muscle pain in the hand or wrist

Exclusion Criteria

All Groups
pregnant women; minors (under age 18); mentally disabled; any persons incarcerated, on parole, on probation, or awaiting trial
individuals with concomitant musculoskeletal pathologies (other than osteoarthritis) in the hand or wrist, including distal radius fracture, contracture, trigger finger, and carpal tunnel
individuals with history of uncontrolled diabetes, rheumatoid arthritis, muscular dysfunction, or neurological disease
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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