Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease

  • STATUS
    Recruiting
  • End date
    Oct 26, 2026
  • participants needed
    260
  • sponsor
    Mario Castro, MD, MPH
Updated on 16 March 2021

Summary

The purpose of this study is to develop and evaluate the usefulness of hyperpolarized (HP) 129Xe gas MRI for regional assessment of pulmonary function.

Description

This is an unblinded, open-label study with ~160 subjects with diagnosed pulmonary disease and ~100 healthy controls. Subjects to be enrolled will include males and females 18-80 years old. Evaluation will be on an outpatient basis. Imaging will be done on a single day and will involve administration of up to four 1-liter doses of HP 129Xe plus one 129Xe calibration dose (~300-400mL HP 129Xe). In addition to 129Xe MRI, a series of anatomical conventional 1H MR images will be collected including a localizer scan, breath-hold spin echo image, and breath-hold steady-state free precession image to highlight the vasculature. All subjects will be evaluated at one center: The University of Kansas Medical Center, KS USA.

Details
Condition Pulmonary Disease, Lung Disease, Cystic Fibrosis, Cystic Fibrosis, Chronic Obstructive Lung Disease, COPD (Chronic Obstructive Pulmonary Disease), Chronic Obstructive Lung Disease, Pancreatic disorder, Pancreatic Disorders, Pulmonary Hypertension, Effects of Chemotherapy, Anemic Cancer, Habit Reversal, Surviving Abuse, Abdominal Surgery, Primary Insulin Hypersecretion, Open Heart Surgery, Cancer Prevention, Stasis Dermatitis, Nerve Injury, Pseudobulbar Affect, Joint Injuries, Chronic Pelvic Pain, Pelvic Adhesions, Mental Disability, Dental Filling, Low Testosterone, Myopic Macular Degeneration, Spinocerebellar Disorders, Complicated Grief, Serial Evaluation of Ductal Epithelium, Renal Anemia, Chronic Renal Anemia, Recurrent Pregnancy Loss, Testotoxikose, Functional Dyspepsia, Pulmonary Arterial Hypertension, Infantile Fibrosarcoma, Severe Premenstrual Symptom, Partial Medial Meniscectomy, Memory Problems, Gambling Problems, Cancer Treatment, Indikation: Diabetes - Typ II, Spine Athroplasty, Catheter Complications, Late Infantile Neuronal Ceroid Lipfuscinsosis, Pulmonary Fibrosis, Pulmonary Fibrosis, Asthma, Asthma, Asthma (Pediatric), Allergies & Asthma, Interstitial lung disease, Cancer Prevention, Surviving Abuse, Joint Injuries, Allergies & Asthma, Pancreatic Disorders, Abdominal Surgery, Mental Disability, Pelvic Adhesions, Low Testosterone, Dental Filling, Habit Reversal, Complicated Grief, Chronic Pelvic Pain, Gambling Problems, Myopic Macular Degeneration, Nerve Injury, Severe Premenstrual Symptom, COPD (Chronic Obstructive Pulmonary Disease), Stasis Dermatitis, Pulmonary Arterial Hypertension, Open Heart Surgery, Asthma (Pediatric), Recurrent Pregnancy Loss, Effects of Chemotherapy, Renal Anemia, Functional Dyspepsia, Catheter Complications, Serial Evaluation of Ductal Epithelium, Chronic Renal Anemia, Reactive Airway Disease, Cancer Treatment, Anemic Cancer, Spinocerebellar Disorders, Pseudobulbar Affect, Spine Athroplasty, Indikation: Diabetes - Typ II, Partial Medial Meniscectomy, Primary Insulin Hypersecretion, Testotoxikose, Infantile Fibrosarcoma, Late Infantile Neuronal Ceroid Lipfuscinsosis, Pulmonary Infection, Lung Infection, Lung Disease, Memory Problems, chronic obstructive pulmonary disease, interstitial lung diseases, asthmatic, bronchial asthma, COPD, chronic obstructive pulmonary disease (copd), Other Lung Disease
Treatment Hyperpolarized Xe129
Clinical Study IdentifierNCT04624490
SponsorMario Castro, MD, MPH
Last Modified on16 March 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Healthy Volunteers
Subject has no diagnosed pulmonary conditions
Ability to read and understand English or Spanish
Subjects with Lung Disease
Subject has a diagnosis of pulmonary dysfunction made by a physician
No acute worsening of pulmonary function in the past 30 days
Ability to read and understand English or Spanish

Exclusion Criteria

MRI is contraindicated based on responses to MRI screening questionnaire
Subject is pregnant or lactating
Subject does not fit into 129Xe vest coil used for MRI
Subject cannot hold his/her breath for 15-16 seconds
Subject deemed unlikely to be able to comply with instructions during imaging
Oxygen saturation <88% on room air or with supplemental oxygen
Cognitive deficits that preclude ability to provide consent
Institutionalization
Clear my responses

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