PET Imaging With [18F]F-AraG in Advanced Non-small Cell Lung Cancer (NSCLC)

  • STATUS
    Recruiting
  • End date
    Feb 1, 2027
  • participants needed
    20
  • sponsor
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Updated on 12 March 2021

Summary

This is a prospective, single center, single-arm clinical trial in 20 patients with non-small cell lung cancer (NSCLC) undergoing PD-1/PD-L1-directed therapy. This research is being done to find out if the radioactive compound called [18F]F-AraG is a helpful imaging agent for detecting changes in cancer's anti-tumor immune response (or activation of T-cell) levels for non-small cell lung cancer (NSCLC) patients who will receive a cancer immunotherapy regimen (immunotherapy works by encouraging the body's own immune system to attack the cancer cells).

Description

The purpose of this study is to find out how the radiotracer called [18F]F-AraG can help investigate changes in cancer's anti-tumor immune response (or activation of T-cell) levels during positron emission tomography (PET) scans. [18F]F-AraG has the potential to serve as a noninvasive imaging biomarker in the monitoring of T-cell mediated anti-tumor immune response following administration of an immunotherapeutic agent.

Participants in this study will have tests, exams and procedures that are for study purposes. Participants will be in this study up to one month which will include about three clinic visits.

A baseline [18F]F-AraG PET-CT will be obtained 0-7 days before a NSCLC patient receives PD-1/PD-L1 immunotherapy. A second [18F]F-AraG PET-CT will be performed 10-14 days after PD-1/PD-L1 immunotherapy is administered.

Details
Condition Non-Small Cell Lung Cancer, nsclc
Treatment [18F]F-AraG Injection
Clinical Study IdentifierNCT04524195
SponsorSidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Last Modified on12 March 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Age 18 years or older and willing and able to provide informed consent
Subjects with stage I, II, or III A NSCLC and plan to receive neoadjuvant PD-1/PD-L1 immunotherapy with an intention for curative surgery. Subjects will be receiving neoadjuvant immunotherapy through enrollment in therapeutic clinical trials
Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2 at the time of enrollment
For females of childbearing potential, negative serum pregnancy test within a 10 day period will be obtained prior to PET study

Exclusion Criteria

Severe impaired renal function with estimated glomerular filtration rate <30 mL/min/1.73 m2 and/or on dialysis
Pregnant female patients; breastfeeding female patients
Any medical condition that in the opinion of the study investigators would constitute a safety risk to the subject
Any investigational radiation exposure in the past calendar year that in combination with the radiation exposure from this study would exceed 5 rem
Administered a radioisotope 5 physical half-lives prior to the day of PET/CT
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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