LVRS Versus BLVR in Patients With Homogenous Emphysema CLUB-HE Trial

  • End date
    Nov 3, 2024
  • participants needed
  • sponsor
    Universität Duisburg-Essen
Updated on 3 October 2021


This is a prospective randomized clinical trial comparing surgical and bronchoscopic lung volume reduction in patients with advanced homogeneous emphysema suitable for both procedures.


Lung volume reduction surgery (LVRS) as well as bronchoscopic lung volume reduction (BLVR) provide functional improvements in selected patients with homogenous emphysema and pronounced hyperinflation. A direct comparison of LVRS and BLVR in patients with homogenous emphysema is not available, thus the study will provide important data to guide treatment selection in this patient population.

Condition Emphysema or COPD
Treatment Lung volume reduction surgery, Bronchoscopic lung volume reduction, Bronchoscopic lung volume reduction
Clinical Study IdentifierNCT04781582
SponsorUniversität Duisburg-Essen
Last Modified on3 October 2021


Yes No Not Sure

Inclusion Criteria

Age 18 years
FEV1 < 50% predicted after bronchodilatation
Significant hyperinflation (TLC >100% predicted, RV > 200% predicted, RV/TLC > 60%)
Non-smoker or ex-smoker for > 3 months (documented by cotinine testing)
MWT >150 m and 450m
MRC dyspnea score > 3
Homogenous emphysema as assessed by HR-CT (< 15% difference in emphysema destruction score between target lobe and ipsilateral lobe) [16, 17]
Uni- or bilateral collateral ventilation (CV) negative result assessed fissure completeness>95% in QCT and confirmed by a bronchoscopic procedure (Chartis)
Optimal medical therapy for > 3months, sufficient rehabilitation status with no need for further training/rehabilitation or rehabilitation within 6 months prior to intervention
Body Mass Index (BMI) > 18, but < 35 kg/m2
Daily dose of prednisone 10mg

Exclusion Criteria

Contraindication against either LVRS or BLVR and/or to surgery and bronchoscopy in general
Major comorbidities limiting survival
Age 80 years
Nicotine abuse within 3 months (documented by cotinine testing)
Predominance of either left or right lung of >70% in perfusion SPECT scintigraphy
FEV1 and/or DLCO <20% predicted (post bronchodilatation)
Untreated Hypoxemia (PaO2 < 50 mmHg)
Untreated Hypercapnia (PaCO2 > 50 mmHg)
Significant pulmonary fibrosis or bronchiectasis
Destroyed/vanished lung on HR-CT
Previous chest surgery or bronchoscopic interventions
Pulmonary hypertension (sPAP > 35 mmHg)
Active waiting list for lung transplantation
Patient is not able to understand and willing to sign a written informed consent document
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact



Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note