High Frequency Oscillatory Ventilation Versus High Frequency Jet Ventilation for Congenital Diaphragmatic Hernia

  • End date
    Dec 31, 2022
  • participants needed
  • sponsor
    University of Utah
Updated on 14 March 2021


The purpose of this study is to conduct a prospective study of all congenital diaphragmatic hernia (CDH) neonates managed at the University of Utah newborn intensive care unit (NICU) and Primary Children's Hospital NICU that required mechanical ventilation at birth. As both high frequency jet ventilation (HFJV) and high frequency oscillatory ventilation (HFOV) are standard approaches to ventilatory support of all neonates including CDH, CDH infants will be randomized at the time of birth or admission to either HFJV or HFOV as initial ventilator mode, stratified by position of the liver in the abdomen or thorax (if known) by 24 hours of age. Measures of oxygenation, ventilation and hemodynamics of the CDH cohort managed on HFOV compared to those on HFJV.

Condition CONGENITAL ANOMALY NOS, Growth Hormone Deficiencies/Abnormalities, Female Hormonal Deficiencies/Abnormalities, Male Hormonal Deficiencies/Abnormalities, Birth Defects, Growth Hormone Deficiencies/Abnormalities, Female Hormonal Deficiencies/Abnormalities, Male Hormonal Deficiencies/Abnormalities, Congenital Diaphragmatic Hernia, Birth Defects
Treatment High Frequency Jet Ventilator, High Frequency Oscillatory Ventilator
Clinical Study IdentifierNCT04774848
SponsorUniversity of Utah
Last Modified on14 March 2021


Yes No Not Sure

Inclusion Criteria

Admitted to either the University of Utah and/or Primary Children's Hospital NICU within 24 hours of birth
Requiring mechanical ventilation
Umbilical arterial line or peripheral arterial line in place
Obtained signed consent
Infant is 24 hours of age

Exclusion Criteria

Severe anomaly
Chromosomal abnormalities
Major congenital anomalies, including cardiac, central nervous system and syndromes
Post-natal diagnosis > 24 hours of life
Unable to obtain consent for participation
Unable to randomize within 24 hours of life
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