High Dose Vitamin A in Preventing Gastrointestinal GVHD in Participants Undergoing Donor Stem Cell Transplant

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  • sponsor
    Ohio State University Comprehensive Cancer Center
Updated on 7 February 2023


This phase I trial studies the side effects and how well high dose vitamin A works in preventing gastrointestinal graft versus host disease (GVHD) in participants undergoing donor stem cell transplant. Vitamin A deficiency is associated with increased risk of gastrointestinal GVHD. Vitamin A regulates growth and differentiation of intestinal cells and may reduce risk of gastrointestinal GVHD.



I. To assess the feasibility and safety of pre-transplant single, high dose vitamin A supplementation in adult allogeneic stem cell transplant recipients until day +28 after transplant.

OUTLINE: This is a dose-escalation study.

Participants receive vitamin A compound orally (PO) or enterally once prior to stem cell transplant.

After completion of study treatment, participants are followed up periodically.

Condition Allogeneic Hematopoietic Stem Cell Transplantation Recipient
Treatment Vitamin A Compound
Clinical Study IdentifierNCT03719092
SponsorOhio State University Comprehensive Cancer Center
Last Modified on7 February 2023

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