Determination of COVID-19 Related Virus in Central Nervous System

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    IRCCS San Raffaele
Updated on 12 March 2021


Coronavirus disease 2019 (COVID-19) is a highly infectious pandemic disease caused by SARS-CoV-2 virus. Central Nervous System (CNS) complications associated with COVID-19 might be secondary sequelae due to exuberant systemic innate-mediated hyper-inflammation, which may impair neurovascular endothelial function, disrupt blood brain barrier (BBB), activates CNS innate immune signaling pathways, and induces parainfectious autoimmunity, potentially contributing to the CNS manifestations. Although the predominant clinical manifestation of SARS-CoV-2 is characterized by dyspnea, unremitting fever and hypoxemic respiratory failure, neurologic manifestations do occur in most hospitalized SARS-CoV-2 patients and include non-specific encephalopathy, psychosis, meningitis/encephalitis, myelitis, cerebrovascular events, Guillain-Barre' syndrome, and cranial or peripheral neuropathies, such as anosmia and ageusia. To date, data about primary CNS involvement due to neurotropism and direct neuroinvasion are still lacking.


Determination of SARS-CoV-2 presence in central nervous system

Condition Central Nervous System Infection, CNS disorder, cns infections, cns infection, infectious disease of central nervous system, cns disease, diseases of the central nervous system, central nervous system disorders, central nervous system disease, disorder central nervous system, COVID-19 Testing, COVID-19 Testing, COVID-19 Testing
Treatment Determination of SARS-CoV2 presence in CNS
Clinical Study IdentifierNCT04775784
SponsorIRCCS San Raffaele
Last Modified on12 March 2021


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