Pancreatitis - Microbiome As Predictor of Severity

  • STATUS
    Recruiting
  • days left to enroll
    15
  • participants needed
    400
  • sponsor
    University Medical Center Goettingen
Updated on 20 May 2021

Summary

This study is a multicentric prospective study initiated and coordinated from the University Medical Centre Goettingen. The study aims to evaluate the orointestinal microbiome as a potential biomarker for the course, severity and outcome of patients with acute pancreatitis.

Description

This prospective translational study aims to evaluate the orointestinal microbiome as a potential biomarker for the course, severity and outcome of patients with acute pancreatitis. From each patient one buccal and rectal swab is collected within 72 h after hospital admission. Microbial composition will be determined by 16S and metagenomics Oxford Nanopore Sequencing (ONT) and correlated with the revised Atlanta classification as the primary endpoint. Secondary endpoints are the correlation of microbiome signatures with the length of hospital stay, numbers of interventions and mortality. To this end, alpha and beta diversity of microbiota are determined and compared between mild, moderately severe and severe acute pancreatitis.

Details
Condition Acute Pancreatitis
Treatment Rectal and buccal swabs
Clinical Study IdentifierNCT04777812
SponsorUniversity Medical Center Goettingen
Last Modified on20 May 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients with acute pancreatitis (2 out of 3 following diagnostic criteria
lipase >3x of upper limit, abdominal pain, and imaging modalities (computed
tomography, magnetic resonance imaging or ultrasound)
< 72 hours after hospital admission

Exclusion Criteria

Pregnant women Patients < 18 years; Patients who are incapable of giving
consent
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