Pain Inflammation and Opioid Craving

  • End date
    Jul 31, 2023
  • participants needed
  • sponsor
    Mclean Hospital
Updated on 23 July 2021


The goal of this study is to investigate the association between response to pain and opioid craving in people with opioid use disorder. In this study, adults with opioid use disorder will be randomized to one of two brief education sessions followed by an assessment of response to pain. Investigators will test the association between response to pain and opioid craving.

Condition Opioid Use Disorder
Treatment Pain education, Pain De-Catastrophizing
Clinical Study IdentifierNCT04190563
SponsorMclean Hospital
Last Modified on23 July 2021


Yes No Not Sure

Inclusion Criteria

age 18 years or older
diagnosis of opioid use disorder
chronic pain
ability to read and provide informed consent

Exclusion Criteria

major psychiatric or medical condition that would interfere with participation
current opioid withdrawal
currently receiving opioid analgesic medication for pain
recent history of myocardial infarction or other serious cardiovascular condition
current peripheral neuropathy, active vasculitis or severe peripheral vascular disease
systematic inflammatory or autoimmune disorder
admitted to current treatment episode on an involuntary status
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How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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