A Phase 2 Trial of Combination Therapies With Adagrasib in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation (202200050434)

  • End date
    Dec 23, 2025
  • participants needed
  • sponsor
    Mirati Therapeutics Inc.
Updated on 20 December 2022


Study 849-017 is an open-label, Phase 2 clinical trial evaluating the clinical efficacy of combination therapies with adagrasib in patients with advanced NSCLC with TPS ≥ 1% and KRAS G12C mutation


Condition Advanced NSCLC, Metastatic Lung Cancer
Treatment Pembrolizumab, Adagrasib in combination with pembrolizumab
Clinical Study IdentifierNCT05609578
SponsorMirati Therapeutics Inc.
Last Modified on20 December 2022


Yes No Not Sure

Inclusion Criteria

Histologically confirmed diagnosis of unresectable or metastatic NSCLC (squamous or nonsquamous) with KRAS G12C mutation and PD-L1 TPS ≥ 1%

Exclusion Criteria

Prior systemic treatment for locally advanced or metastatic NSCLC, including chemotherapy, immune checkpoint inhibitor therapy (CIT), or any therapy targeting KRAS G12C mutation (eg, sotorasib)
Active brain metastases
Radiation to the lung ≥ 30 Gy within 6 months prior to first dose of study treatment
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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