Diagnostic Classifier for Cutaneous T-cell Lymphomas

  • STATUS
    Recruiting
  • End date
    Jun 30, 2024
  • participants needed
    160
  • sponsor
    Medical University of Vienna
Updated on 21 April 2022

Summary

Primary cutaneous T-cell lymphomas (CTCL) are a form of skin cancer that is derived from immune cells. The most common form of CTCL is mycosis fungoides (MF). While initially confined to the skin, MF may spread to lymph nodes, blood or inner organs, resulting in an overall poor prognosis for the patient. Thus, being a potentially lethal disease, an early and correct diagnosis of MF has very important implications for the patient. However, diagnosis of early MF is often difficult, as it usually shows a close resemblance to benign inflammatory conditions such as eczema and psoriasis. Strikingly, it takes an average of 3-6 (!) years from the appearance of the first skin lesions until a diagnosis of MF can be made. For this reason, a test to distinguishing early MF from benign inflammatory conditions is urgently mandated. By using skin suction blister fluid as well as skin biopsies from patients with MF, eczema and psoriasis, the investigators want to develop a classifier system that can distinguish early MF from benign inflammatory skin diseases.

Details
Condition CTCL/ Mycosis Fungoides
Treatment Skin suction blistering and skin biopsies
Clinical Study IdentifierNCT04491825
SponsorMedical University of Vienna
Last Modified on21 April 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Clinical and/or histopathological diagnosis of MF, eczema or psoriasis
Healthy control subjects without personal history of MF, eczema or psoriasis

Exclusion Criteria

Ongoing skin-targeted treatment (Wash out times: 2 weeks for topical, and 4 weeks for systemic treatments)
Ongoing other treatment that might, in the opinion of the investigator, influence proteomic features of the samples to be acquired
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