Renin Angiotensin System Blockade in Renal Transplant Patients With Presence of PECs in Urine

  • STATUS
    Recruiting
  • End date
    Jun 27, 2023
  • participants needed
    180
  • sponsor
    Josep M Cruzado
Updated on 27 May 2021

Summary

By means of a personalized medicine strategy, investigators are going to evaluate if the treatment with an angiotensin II receptor antagonist (ARAII) in renal transplant patients with the presence of renal progenitor cells (PECs) in the urine is able to prevent the expected loss of glomerular filtration (GFR) observed in this subgroup of patients. In addition, investigators intend to deepen the mechanisms of glomerular damage and glomerular repair involved in the process of chronic allograft damage.

Description

A randomized, double-blind clinical trial will be performed in renal transplant patients in month 6 post-transplant, at the time of protocol renal biopsy. After verifying the inclusion and exclusion criteria, informed consent will be obtained. Patients with urinary PECs will be randomized to 80 mg of valsartan vs. placebo (sample size calculated for a superiority study, 45 patients per group). Patients without PECs in urine will be followed according to usual clinical practice. The follow-up will be up to 2 years post-transplant. At baseline (6 m post-transplant) and at 2 years the GFR will be measured by means of iohexol clearance (main variable) and, in addition, we will analyze safety variables such as patient and graft survival and RAGIs. By means of morphometry techniques on renal biopsy and by measuring the renal cortical volume by high resolution CT, the number of glomeruli will be determined, which in turn, will allow to calculate the SN-GFR. Finally, in 5 patients per study group and in 5 controls, PECs of renal tissue will be isolated by means of laser microdissection techniques to perform single-cell RNA sequencing techniques to assess the molecular pathways involved in the glomerular damage and repair process and how the RAAS blockade modifies such molecular pathways.

Details
Condition Chronic Kidney Allograft Nephropathy
Treatment Valsartan 80Mg Oral Tablet
Clinical Study IdentifierNCT04769778
SponsorJosep M Cruzado
Last Modified on27 May 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Written informed consent
Stable renal function understood as a variation of eGFR of less than 15% in the last 3 months
Immunosuppression maintenance based on tacrolimus and MMF / MPA

Exclusion Criteria

Chronic active infection by HCV, HBV, HIV
Treatment with inhibitors of the renin angiotensin system
Double kidney transplant or combined with another organ
Immunosuppression of maintenance other than tacrolimus and MMF / MPA
eGFR <20 ml / min / 1.73m2
History of allergy or intolerance to inhibitors of the renin angiotensin system
Physically fertile women who plan to become pregnant, are pregnant and
or breast-feeding, or who do not want to use effective contraception during
their participation in the study
Any other medical condition that, in the opinion of the investigator, based on the counting or review of clinical records, could affect the completion of the study, including, but not limited to, visual problems or cognitive impairment
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