Atezolizumab Plus 8 Gy Single-fraction Radiotherapy for Advanced Oligoprogressive NSCLC
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- STATUS
- Recruiting
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- End date
- Dec 31, 2022
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- participants needed
- 20
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- sponsor
- Oncology Institute of Southern Switzerland
Summary
Multicentre, phase II, open-label, single-arm study evaluating the preliminary efficacy, safety and tolerability of atezolizumab in association with palliative radiotherapy in adult patients diagnosed with advanced (stage IV) NSCLC, irrespective of PD-L1 status, and who have oligoprogressed to both immunotherapy with an anti PD-1 agent (e.g., pembrolizumab or nivolumab) and 1 line of chemotherapy.
Description
Atezolizumab will be administered at a fixed dose of 1,200 mg by intravenous infusion every 21 days on an outpatient basis according to the its approved prescribing information. Palliative radiation therapy will be delivered concomitant to the 2nd dose of atezolizumab as a single fraction of 8 Gy to all eligible metastatic and primary sites.
Details
| Condition | NSCLC Stage IV |
|---|---|
| Treatment | Atezolizumab |
| Clinical Study Identifier | NCT04549428 |
| Sponsor | Oncology Institute of Southern Switzerland |
| Last Modified on | 13 May 2022 |
Eligibility
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