Intraperitoneal Injection of Oncolytic Viruses H101 for Patients With Refractory Malignant Ascites

  • STATUS
    Recruiting
  • days left to enroll
    28
  • participants needed
    25
  • sponsor
    Fudan University
Updated on 24 April 2021

Summary

Assessment of effectiveness and local immune activation of Oncolytic Viruses H101 in patients with refractory malignant ascites.

Description

This study is to evaluate the effectiveness of local immune activation, and safety in patients with refractory malignant ascites after Intraperitoneal injection of oncolytic Viruses H101.

Details
Condition Refractory Malignant Ascites
Treatment Oncorine (H101)
Clinical Study IdentifierNCT04771676
SponsorFudan University
Last Modified on24 April 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Written informed consent obtained
Age 18 years at time of study entry
Cytologically diagnosed solid tumor malignancy
Malignant peritoneal ascites confirmed by peritoneal brush cytology
Failures from chemotherapy against malignant ascites
Cooperative Oncology Group-Status (ECOG Status) 0 or 1

Exclusion Criteria

History or evidence of active autoimmune disease that requires systemic treatment
Acute or chronic active Hepatitis B or C infection or HIV infection
Previous (<4 weeks) or concurrent treatment with systemic or intraperitoneal chemotherapy or biological agents such as monoclonal antibodies
Concurrent severe illness such as active infection
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