Profiling the Skin Microbiome in Response to Altreno in Acne Patients

  • STATUS
    Recruiting
  • End date
    Dec 31, 2022
  • participants needed
    60
  • sponsor
    Beth Israel Deaconess Medical Center
Updated on 22 August 2021

Summary

The study objective is to characterize the shift in the diversity and abundance of the skin microbial community at baseline and in response to Altreno monotherapy as compared to benzoyl peroxide (BPO) 2.5% leave-on gel monotherapy in acne patients.

Description

With the advent of 16S rRNA sequencing, scientific community is beginning to understand the critical importance of the microbiome in human health. In dermatology, researchers have begun to lead the effort to not only better understand how the microbiome contributes to the pathogenesis of skin disease, but also harness its power to develop novel therapies. Acne is a common inflammatory skin disorder. P. acnes on the skin has been traditionally thought of as the culprit bacteria in the pathogenesis of acne.

Recent studies demonstrate that the skin microbial composition dynamically changes in response to systemic acne therapy. Using 16 rRNA gene sequencing, a prior study has confirmed that systemic antibiotic treatment decreased the abundance of P. acnes, which returned to baseline after discontinuation of the therapy. In contrast, the systemic therapy increased the abundance of Pseudomonas species, which returned to baseline after therapy cessation. Based on the opposing response to the therapy, it can be speculated that these two species compete for the same microenvironment within the skin microbiome. Interestingly, the same systemic therapy decreased the abundance of lactobacillus genus, the "good bacteria" that is protective against skin infection, and that decrease was sustained even after cessation of the therapy. Similarly, another study has demonstrated that systemic isotretinoin therapy disturbed the skin microbiome in acne patients with increased bacterial diversity on the cheeks. It is unclear the potential therapeutic role of the increased bacterial diversity in the management of acne patients.

The study aims to characterize the shift in the diversity and abundance of the skin microbial community in response to Altreno in acne patients. Understanding the role of the skin microbiome in response to therapy can help clinicians to develop tailored, targeted treatment options, including reconstitution of "good bacteria." Furthermore, it can lead to development of novel topical pre and probiotics.

Details
Condition Acne Vulgaris, healthy, Acne, acnes
Treatment Altreno, Benzoyl peroxide, Benzoyl peroxide
Clinical Study IdentifierNCT04548349
SponsorBeth Israel Deaconess Medical Center
Last Modified on22 August 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

A confirmed diagnosis of acne that warrants initiating topical medications
Denies use of any prescribed systemic acne treatments in the past 30 days
Denies use of any prescribed topical medications in the past 30 days
Denies use of any OTC topical acne medications in the past 14 days
Denies use of any emollients in the past 24 hours (if feasible)
Denies bathing or facial washing in the past 12 hours (if feasible)
Willingness to adhere to the recommended topical regimen during the duration of the study

Exclusion Criteria

Women who are pregnant, breastfeeding, or planning to get pregnant during the study
Use of any investigational drug(s) in the past 3 months
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