In the proposed study, we will utilize resting-state functional MRI (fMRI) and structural MRI-based electrical field modeling to study the effect of electroconvulsive therapy on human neural circuitry. Our study will recruit patients who are beginning treatment with bilateral electroconvulsive therapy (N=75). Our design will be longitudinal we will follow patients up until their 8th week electroconvulsive therapy clinically. The primary measure of interest will be the slope of clinical change estimated with mixed effect modeling (see Approach). Secondary measures will be the cognitive performance change between baseline and the 8th week electroconvulsive therapy time point.
Condition | Electroconvulsive Therapy Treated Patients |
---|---|
Treatment | clinical and neuropsychological testing |
Clinical Study Identifier | NCT04763655 |
Sponsor | Northwell Health |
Last Modified on | 7 March 2021 |
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