PET Imaging to Delineate Macrophage Activation in Diabetic Gastroparesis

  • End date
    Dec 31, 2022
  • participants needed
  • sponsor
    Mayo Clinic
Updated on 21 July 2021


Macrophage-driven immune dysregulation has been shown to be involved in pathophysiology of diabetic gastroparesis. Currently, there are no non-invasive ways to study macrophage activation in humans. This study aims to determine the utility of 11C-ER176 based PET-CT scanning to determine pro-inflammatory macrophage activation in gastric wall of patients with diabetic gastroparesis.

Condition Diabetes Mellitus, diabetes mellitus (dm), type 2 diabetes mellitus, NIDDM, Diabetes Mellitus, Type 2, Diabetic Gastroparesis, Diabetes, type 2 diabetes, noninsulin-dependent diabetes mellitus, Diabetes Mellitus Type 2, diabetes type 2, Diabetes (Pediatric), Diabetes Mellitus Types I and II, type ii diabetes, Diabetes Prevention
Treatment PET/CT Scan with 11C-ER176, Core biopsy of gastric muscle
Clinical Study IdentifierNCT04762719
SponsorMayo Clinic
Last Modified on21 July 2021


Yes No Not Sure

Inclusion Criteria

Age: 18 to 70 years of age
Ability to provide informed consent
Type I or II diabetes mellitus
Gastroparesis defined by gastric retention of Tc-99m > 60 % at 2 hrs and/or > 10% at 4 hours on scintigraphy
Average Gastroparesis Cardinal Symptom Index (GCSI) 3 indicating moderate-severe symptoms

Exclusion Criteria

Women who are pregnant or cannot stop breast feeding for 24 hours
Using anti-coagulants, anti-inflammatory medications (NSAIDs, corticosteroids, etc.) or immunosuppressive therapies within the 4 weeks prior
Opioid use within the last 4 weeks of gastric emptying scintigraphy
Prior gastric surgery
History of IBD, celiac disease, eosinophilic gastroenteritis, microscopic colitis
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact



Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note