A Single Arm Study of Brain Metastasis in Patients With HER2-positive Breast Cancer

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    Tianjin Medical University Cancer Institute and Hospital
Updated on 6 July 2022


The aim of this study was to evaluate the progression time and efficacy of brain tumors in patients with brain metastases from HER2-positive breast cancer treated with Pyrrolidine and Capecitabine combined with brain radiotherapy.


Brain metastases are very common in HER2-positive breast cancer patients. The vast majority of patients with metastatic brain tumors are in advanced stages of the disease. If not treated in time, the natural course of the disease is extremely short. At present, the main treatment of brain metastases from breast cancer is radiotherapy, combined with chemotherapy and targeted therapy drugs. On the basis of previous clinical studies, the aim of this study was to explore the efficacy and safety of combined brachytherapy with Pyrrotidine and Capecitabine in patients with brain metastases from HER2-positive breast cancer, in order to provide a new, safer and more effective treatment for patients with brain metastases from breast cancer.

Treatment PYRROTINI, Brain radiation therapy
Clinical Study IdentifierNCT04767828
SponsorTianjin Medical University Cancer Institute and Hospital
Last Modified on6 July 2022

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