Study of a Geriatric Assessment to Plan a Treatment Approach for Older People With Various Blood Disorders
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- STATUS
- Recruiting
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- End date
- Feb 3, 2023
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- participants needed
- 32
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- sponsor
- Memorial Sloan Kettering Cancer Center
Summary
This study will evaluate whether a geriatric assessment can lead to better treatment outcomes in older patients (age 60+) with myelodysplastic syndromes, myeloproliferative neoplasms, or related blood disorders who are going to receive chemotherapy or another treatment to prepare the body for an allogeneic hematopoietic stem cell transplant (allo-HCT). The geriatric assessment includes looking at patients' cognitive function (thinking processes), physical function, mobility (ability to move the body), mood, nutrition, and current medications to help decide the type of treatment they'll receive.
Another purpose of this study is to see whether use of the geriatric assessment improves participants' quality of life. We will evaluate participants' quality of life through questionnaires.
Description
This is a prospective, phase II study evaluating the efficacy of a risk-adapted, personalized allo-HCT strategy based on geriatric vulnerabilities identified by pre-transplant GA. The less vulnerable/fit older patients are recommended to receive MA conditioning and the more vulnerable older patients are recommended to receive RIC/NMA conditioning.
- HCT-CI/Age 4 AND no IADL impairment (less vulnerable/fit) -> MA regimen
- HCT-CI/Age >4 AND/OR any IADL impairment (more vulnerable) -> RIC/NMA regimen
- Chemotherapies: busulfan, fludarabine, melphalan, cyclophosphamide, thiotepa, clofarabine
- Radiation therapy: total body irradiation (TBI)
- Other therapy: anti-thymocyte globulin (ATG)
Details
| Condition | Bone marrow disorder, Chronic myelomonocytic leukemia, Juvenile Myelomonocytic Leukemia, Preleukemia, Philadelphia-Negative Myelogenous Leukemia, MYELOPROLIFERATIVE DISORDER, MYELODYSPLASTIC SYNDROME, Myelodysplastic Syndromes (MDS), Myeloproliferative Neoplasms, myelodysplastic syndromes, myeloproliferative neoplasm, myeloproliferative disorders, atypical chronic myeloid leukemia, myelodysplastic syndrome (mds), chronic myelomonocytic leukaemia, cmml, Myelodysplastic/Myeloproliferative Overlapping Syndrome, Myelodysplastic/Myeloproliferative Overlapping Syndrome |
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| Treatment | Conditioning regimen, Geriatric assessment (GA) pre-transplant, Allogeneic CD34+ selected stem cells |
| Clinical Study Identifier | NCT04761770 |
| Sponsor | Memorial Sloan Kettering Cancer Center |
| Last Modified on | 3 March 2021 |
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