Network-targeted Theta-burst Stimulation for Episodic Memory Improvement in Mild Cognitive Impairment

  • End date
    Jun 30, 2025
  • participants needed
  • sponsor
    University of California, Los Angeles
Updated on 22 February 2021


The purpose of this study is to see if stimulation of the brain can improve memory. The investigators will use a device called transcranial magnetic stimulation that can stimulate and activate a specific part of the brain that is important for memory. The study will enroll MCI subjects who will be randomly assigned to receive active or sham brain stimulation. 'Blinded' or 'sham-controlled' means that the subject will not know whether the treatment they receive is the active treatment or the non-active stimulation. In the 'sham' condition, the stimulator will turn on but will not actually be stimulating the target brain region.

Condition Cognitive Impairment, Cognitive Dysfunction, Cognitive Impairments, neurocognitive disturbance, Memory Disorders in Old Age
Treatment sham theta burst stimulation, Active Theta Burst Stimulation
Clinical Study IdentifierNCT04558164
SponsorUniversity of California, Los Angeles
Last Modified on22 February 2021


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Inclusion Criteria

Is your age between 55 yrs and 90 yrs?
Gender: Male or Female
Do you have any of these conditions: Cognitive Impairment or neurocognitive disturbance or Cognitive Impairments or Memory Disorders in Old Age or Cognitive Dysfunction?
-90 years of age
Willing to provide informed consent and participate in a longitudinal study
In good general health
MoCA (Montreal Cognitive Assessment Test) >25
Ability to read and write English fluently
Adequate visual and auditory acuity to allow neuropsychological testing
Screening laboratory/ECG without abnormalities that might interfere with the study
Diagnosis of mild neurocognitive disorder according to DSM-5 (Diagnostic and Statistical Manual of Mental Disorders) criteria

Exclusion Criteria

Diagnosis of dementia
Active major psychiatric or neurologic disorders
Active alcohol or substance abuse
Recent (< 6 months) alcohol or substance abuse excluding nicotine or caffeine
Active or history of stroke, traumatic brain injury with loss of consciousness, or other neurologic disorder (e.g., Epilepsy, Huntington's disease, Parkinson's disease)
Not a native English Speaker
Not right handed based on self-report or evaluation based on a standard report
Has received TMS before (not TMS nave)
Head trauma or systemic diseases affecting brain function
Uncontrolled hypertension or cardiovascular disease
Use of any memory-enhancing medication (e.g., memantine, cholinesterase inhibitor), supplement (e.g., ginkgo biloba), or psychotropic medication for treatment of depression, anxiety, or psychosis
Current enrollment in a memory-enhancement study or course
Contraindication to the MRI including claustrophobia, metal in body, surgery within 60 days, certain implants or previous abnormal MRI results
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