Second Uterine Evacuation for Low-risk Gestational Trophoblastic Neoplasia

  • STATUS
    Recruiting
  • End date
    Dec 31, 2025
  • participants needed
    150
  • sponsor
    Brigham and Women's Hospital
Updated on 21 February 2021

Summary

To evaluate the efficacy and safety of second uterine curettage in patients with low-risk non-metastatic GTN.

Description

This is a randomized, multicenter clinical trial including patients seen at one of 13 gestational trophoblastic disease reference centers in Brazil. Subjects are eligible if they have low-risk gestational trophoblastic neoplasia according to FIGO 2000 criteria and the FIGO/WHO prognostic risk score. The study includes two treatment arms: immediate treatment with single-agent chemotherapy (center choice of agent) or second uterine curettage. The primary outcome is the rate of primary remission. Secondary outcomes are the number of chemotherapy cycles required to achieve remission, rate of primary chemotherapy resistance, rate of relapse, and overall survival.

Details
Condition Hydatidiform Mole, Gestational trophoblastic disease, Gestational Trophoblastic Neoplasia, molar pregnancy, molar pregnancies, Gestational Trophoblastic Tumor, Non-Metastatic, Gestational Trophoblastic Tumor, Non-Metastatic
Treatment Chemotherapy, Uterine curettage
Clinical Study IdentifierNCT04756713
SponsorBrigham and Women's Hospital
Last Modified on21 February 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Histopathological diagnosis of molar pegnancy according to the morphological criteria described by Sebire et al., who meet the diagnostic criteria for low-risk non-metastatic GTN according to FIGO 2000 criteria

Exclusion Criteria

High risk GTN (FIGO risk score 7) or metastatic disease at diagnosis of GTN (stage II, III or IV)
Histopathological diagnosis of choriocarcinoma, placental site trophoblastic or epithelioid trophoblastic tumor at the second curettage
Previous chemotherapy treatment
Level of hCG at the time of GTN diagnosis less than 20 IU/L (to minimize the risk of inclusion of patients with false positive hCG, either by cross-reaction with pituitary hormones or by the presence of circulating heterophilic antibodies)
Relapsed GTN
Incomplete medical records
Loss to follow-up
Voluntary desire to stop participating in the study
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