Kharituwe TB Contact Tracing Study

  • End date
    Jun 23, 2024
  • participants needed
  • sponsor
    Johns Hopkins Bloomberg School of Public Health
Updated on 23 February 2021


The purpose of this study is to characterize the role of human mobility in fueling TB epidemics and estimate the potential impact of innovative case finding interventions tailored to mobile populations


The investigators propose a randomized trial of two novel TB case-finding interventions among household members of patients diagnosed with active TB: holiday-based screening in a rural South African province (Limpopo) and off-peak (weekend/evening) screening in an urban settlement into which many residents of Limpopo migrate for work. The investigators will enroll index cases of TB plus their household contacts in each setting and randomize them to novel versus standard contact investigation. In Specific Aim 1, investigators will use whole genome sequencing of all cases, overlaying transmission trees with data on human movement, to evaluate associations between mobility and TB transmission in this population. In Specific Aim 2, investigators will employ a multidisciplinary approach to compare novel versus standard contact investigation in each setting along the following dimensions: (a) effectiveness (number of secondary TB cases diagnosed and starting treatment); (b) implementation (reach, fidelity, and maintenance of contact investigation outside of business hours); (c) cost-effectiveness (cost per disability-adjusted life year) and budget impact; and (d) projected population-level impact on TB incidence. Successful completion of these aims will have long-term impact by characterizing the role of mobility in fueling TB epidemics and testing two tailored approaches to improve TB control in highly mobile populations - an underserved group that is increasingly recognized as playing a major role in global TB transmission.

Condition Tuberculosis, HIV, HIV positive, HIV infection, AIDS Vaccines, HIV (Pediatric), HIV Infections, tb (tuberculosis), human immunodeficiency virus, hiv disease, HIV Vaccine, hiv vaccines
Treatment Household contact tracing
Clinical Study IdentifierNCT04520113
SponsorJohns Hopkins Bloomberg School of Public Health
Last Modified on23 February 2021


Yes No Not Sure

Inclusion Criteria

Age 0-99 years
Currently resides with or visiting eligible TB index case

Exclusion Criteria

Unwilling/unable to provide informed consent
Unwilling/unable to comply with study procedures
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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