Short-course Antibiotic Treatment in Gram-positive Cocci Infective Endocarditis

  • STATUS
    Recruiting
  • End date
    Sep 30, 2022
  • participants needed
    298
  • sponsor
    Carmen Olmos Blanco
Updated on 18 February 2021

Summary

Background: it is well known that most serious complications of infective endocarditis (IE) appear in the so-called "critical phase" of the disease, which are the first days after diagnosis. Subsequently, the vast majority of patients who overcome this acute phase has a favourable evolution, and usually stay in the hospital for a long time only to complete antibiotic therapy.

In stable patients with adequate response to antibiotic treatment, without signs of persistent infection or metastatic foci such as spondylodiscitis, it is likely that a shorter antibiotic regimen would be an efficient and safe alternative, as has already been confirmed in patients with IE on tricuspid valves caused by a microorganism considered virulent such as S. aureus. This attractive alternative would improve patients' quality of life, save costs, and decrease the risk of complications related to the adverse effects of prolonged antibiotic treatment.

Objectives: to compare the incidence of the composite endpoint of all-cause mortality, unplanned cardiac surgery, symptomatic embolisms and relapses within 6 months after the inclusion between patients with IE caused by gram-positive cocci receiving a short-course of 2 weeks of antibiotic therapy and those patients receiving conventional antibiotic therapy (4-6 weeks).

Methodology: multicenter, prospective, randomized, controlled open-label, phase IV clinical trial. Sample: patients with IE caused by gram-positive cocci, having received at least 10 days of conventional antibiotic treatment, and at least 7 days after surgery when indicated, without clinical, analytical, microbiological or echocardiographic signs of persistent infection. Estimated sample size: 298 patients. Intervention: Control group: standard antibiotic therapy, according to ESC guidelines recommendations, for 4 to 6 weeks. Experimental group: short-course antibiotic therapy for 2 weeks. The prevalence of previously known risk factors for adverse events will be compared between the two groups to confirm that randomization have worked properly. The incidence of the composite endpoint of all-cause mortality, unplanned cardiac surgery, symptomatic embolisms and relapses within 6 months after the inclusion in the study will be prospectively registered and compared.

Details
Condition Bacterial Endocarditis
Treatment Antibiotics
Clinical Study IdentifierNCT04222257
SponsorCarmen Olmos Blanco
Last Modified on18 February 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Is your age greater than or equal to 18 yrs?
Gender: Male or Female
Do you have any of these conditions: Do you have Bacterial Endocarditis??
Definite IE, according to modified ESC 2015 criteria, caused by gram-positive cocci (staphylococci, streptococci and enterococci), including native, prosthetic valve IE and cardiac device-related IE
years old or older
Patients treated for at least 10 days of appropriate parenteral antibiotic therapy overall (according to guidelines and microbiology sensitivity testing), and at least 7 days of parenteral antibiotic therapy after valve surgery when indicated
Absence of fever, microbiological or analytical findings suggesting persistent infection at randomization
Absence of locally uncontrolled infection signs (abscess, pseudoaneurysm, fistula, enlarging vegetation) at randomization, confirmed by recent transesophageal echocardiography (performed within 48 h of randomization)
Women of childbearing potential who will agree to the use of effective contraceptive methods while on antibiotic treatment

Exclusion Criteria

Patients who have received appropriate parenteral antibiotic therapy for infective endocarditis for more than 12 days
Patients not suitable to be discharged after 10 days of conventional treatment, due to clinical reasons (sequels of stroke that prevent discharge, progressive renal failure, hepatic failure)
Patients receiving chemotherapy or immunosuppressive therapy
Pregnant or breastfeeding women
Need of prolonged antibiotic therapy due to spondylodiscitis or other septic complication
Absence of patient's ability or commitment to continue follow-up after being discharged from hospital
Inability to give informed consent to participation
Cognitive impairment or lack of language skills needed to complete the questionnaires
Patients who meet urgent cardiac surgery ESC criteria but are considered inoperable due to high surgical risk
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