HX008 Plus Chemotherapy VS Pembrolizumab Plus Chemotherapy As the First-line Treatment in Participants With Advanced or Metastatic Nonsquamous Non-small Cell Lung Cancer

  • STATUS
    Recruiting
  • End date
    Sep 25, 2023
  • participants needed
    700
  • sponsor
    Taizhou Hanzhong biomedical co. LTD
Updated on 17 February 2021

Summary

This a phase II-III study. In the single-armed phase II period, HX008, a monoclonal antibody targeting PD-1, will be combined with pemetrexed+platinum (Investigators choice of cisplatin or carboplatin) chemotherapy to treat participants with advanced or metastatic nonsquamous non-small cell lung cancer (NSCLC) who have not previously received systemic therapy for advanced disease. When the preliminary efficacy and safety data are acquired, a single-blinded phase III study will ensue, in which the efficacy and safety of HX008+pemetrexed+platinum VS pembrolizumab+pemetrexed+platinum in participants of the same population will be compared head-to-head with 1:1 randomization. The primary endpoints are safety and ORR (overall response rate) evaluated by the investigator in phase II study, and PFS evaluated by IRC (independent review committee) in phase III study. The primary hypothesis in phase III study is that HX008+pemetrexed+platinum is non-inferior to pembrolizumab+pemetrexed+platinum in terms of PFS (Progression-Free Survival).

Details
Condition Nonsquamous Non Small Cell Lung Cancer
Treatment Pembrolizumab, Pemetrexed, Cisplatin/Carboplatin, HX008
Clinical Study IdentifierNCT04750083
SponsorTaizhou Hanzhong biomedical co. LTD
Last Modified on17 February 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Understood and signed an informed consent form
Age 18 years old, male or female
Have a histologically or cytologically confirmed diagnosis of stage IV (M1a or M1bAJCC 7th edition) nonsquamous NSCLC
Have not received prior systemic treatment for their advanced/metastatic NSCLC. Subjects who received adjuvant or neoadjuvant therapy are eligible if the adjuvant/neoadjuvant therapy was completed at least 12 months prior to the development of metastatic disease
Have confirmation that EGFR or ALK-directed therapy is not indicated
Have at least one measurable lesion according to RECIST1.1. Lesions situated in previously irradiated areas could be considered as target lesions if progression has been demonstrated in such lesions. If measurable lesions exist in other areas, lesions in previous irradiated areas should be considered as non-target lesions
Have provided tumor tissue from locations not radiated prior to biopsy for determination of PD-L1 status prior to randomization. Formalin fixed specimens the subject has been diagnosed with metastatic disease will be preferred. Biopsies obtained prior to receipt of adjuvant/neoadjuvant chemotherapy will be permitted if recent biopsy is not feasible
Life expectancy 3 months
Have a performance status of 0 or 1 on the Eastern Cooperative Oncology Group (ECOG) Performance Score
Have adequate organ function as indicated by the following laboratory values
Blood routine: serum albumin 2.5g/dL; absolute neutrophil count (ANC) 1.510^9/L; while blood cell count (WBC) 310^9/L; platelet count (PLT) 10010^9/L; hemoglobin (HGB) 90 g/L (without blood transfusion within 4 weeks prior to enrollment)
Renal function: creatinine clearance (CrCl) 50 mL/min
Liver function: Patients without liver metastases require alanine aminotransferase (ALT) and aspartate aminotransferase (AST) 2.5ULN. Patients with liver metastases require: ALT and AST5ULN. Serum total bilirubin 1.5xULN or direct bilirubin ULN for subjects with total bilirubin levels >1.5xULN
International Normalized Ratio (INR) or Prothrombin Time (PT) 1.5 X ULN unless the subject is receiving anticoagulant therapy; OR activated Partial Thromboplastin Time (aPTT) or Partial Thromboplastin Time (PTT) 1.5 X ULN unless the subject is receiving anticoagulant therapy
If female of childbearing potential, have a negative urine or serum pregnancy test within 72 hours prior to receiving the first dose of study medication. If the urine test is positive or cannot be confirmed as negative, a serum pregnancy test will be required
If female of childbearing potential, be willing to use an adequate method of contraception as outlined in Section 4.3-Contraception, for the course of the study through 120 days after the last dose of study medication or through 180 days after last dose of chemotherapeutic agents as specified in the protocol. If male subject with a female partner(s) of child-bearing potential, must agree to use an adequate method of contraception as outlined in Section 4.3-Contraception, starting with the first dose of study therapy through 120 days after the last dose of study therapy or through 180 days after last dose of chemotherapeutic agents as specified in the protocol. Males with pregnant partners must agree to use a condom; no additional method of contraception is required for the pregnant partner
Note: Abstinence is acceptable if this is the usual lifestyle and preferred
contraception for the subject

Exclusion Criteria

The subject must be excluded from participating in the trial if the subject
Has predominantly squamous cell histology NSCLC. Mixed tumors will be categorized by the predominant cell type; if small cell elements are present, the subject is ineligible
Before the first dose of trial treatment
Has received prior systemic cytotoxic chemotherapy or other antineoplastic therapy (e.g., erlotinib, crizotinib, cetuximab) for metastatic disease
Had major surgery within 3 weeks prior to the first dose of trial treatment
Has participated in other clinical trial within 4 weeks prior to the first dose
Received radiation therapy to the lung that is > 30 Gy within 6 months prior to the first dose
Completed palliative radiotherapy within 7 days prior to the first dose
Has received a live-virus vaccination within 30 days prior to the first dose. Seasonal flu vaccines that do not contain live virus are permitted
Has clinically active diverticulitis, intra-abdominal abscess, GI obstruction, peritoneal carcinomatosis
Suffered from other malignant tumors in the past 5 years, except those with low risk of metastasis and death (5-year survival rate > 90%), for instance, skin basal cell carcinoma, squamous cell carcinoma, and carcinoma in situ from cervix or other regions that have been adequately treated
Has known active central nervous system (CNS) metastases and/or carcinomatous meningitis. Subjects with previously treated brain metastases may participate provided they are clinically stable for at least 2 weeks and, have no evidence of new or enlarging brain metastases and also are off steroids 3 days prior to dosing with study medication. Stable brain metastases by this definition should be established prior to the first dose of study medication. Subjects with known untreated, asymptomatic brain metastases (ie, no neurological symptoms, no requirements for corticosteroids, no or minimal surrounding edema, and no lesion >1.5 cm) may participate but will require regular imaging of the brain as a site of disease
Has a known sensitivity to macromolecular agents or any component of cisplatin, carboplatin or pemetrexed
Has a history of organ or stem-cell transplantation
Has active autoimmune disease that has required systemic treatment in past 2 years (i.e. with use of disease modifying agents, corticosteroids or immunosuppressive drugs). Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment
Has received systemic corticosteroids (a calculated dose >10mg prednisone per day ) or other immunosuppressive drugs within 14 days before the first administration of the study drug, excluding
Nasal spray, inhalation or other local glucocorticoids
Short-term ( 7 days) use of glucocorticoids as a preventive medication for allergic reactions or as a therapeutic medication for non-autoimmune diseases
Is on chronic systemic steroids. Subjects with asthma that require intermittent use of bronchodilators, inhaled steroids, or local steroid injections would not be excluded from the study
Is unable to interrupt aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs), other than an aspirin dose 1.3 g per day, for a 5-day period (8-day period for long-acting agents, such as piroxicam)
Is unable or unwilling to take folic acid or vitamin B12 supplementation
Had prior treatment with any anti-PD-1, or PD-L1 or PD-L2 agent or an antibody targeting other immuno-regulatory receptors or mechanisms. Examples of such antibodies include (but are not limited to) antibodies against IDO, PD-L1, IL-2R, GITR
Has a severe active infection prior to the first administration of the study drug and might not in the best interest of the subject to participate, in the opinion of the Investigator
Has known history of Human Immunodeficiency Virus (HIV) (known HIV 1/2 antibodies positive)
Has known active Hepatitis B or C. Active Hepatitis B is defined as a known positive HBsAg result. Active Hepatitis C is defined by a known positive Hep C Ab result and known quantitative HCV RNA results greater than the lower limits of detection of the assay. Those with HBV DNA viral load or copy number lower than the lower limits of detection of the assay or HCV RNA negative after adequate treatment is eligible
Has known psychiatric or mental disorders, such as epilepsy, dementia, or a known regular user of any illicit drugs, or had a recent history (within the last year) of substance abuse (including alcohol) that would interfere with cooperation with the requirements of the trial
Has symptomatic ascites or pleural effusion. A subject who is clinically stable following treatment for these conditions (including therapeutic paracentesis) is eligible
Has a history of non-infectious pneumonitis that required steroids or active interstitial pneumonia. Other moderate and severe lung diseases that may interfere with the detection or treatment of study drug-related pulmonary toxicity or seriously affect respiratory function, such as idiopathic pulmonary fibrosis, organic pneumonia / bronchiolitis obliterans, etc (except for local pneumonia induced by radiotherapy)
Is pregnant or breastfeeding, or expecting to conceive or father children within the projected duration of the study
Has active tuberculosis
Has uncontrolled systemic diseases, for instance, cardiovascular and cerebrovascular disease, diabetes, hypertension, etc
Has a history or current evidence of any condition, or laboratory abnormality that might not in the best interest of the subject to participate, in the opinion of the Investigator
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