Intranasal Remimazolam for Premedication in Pediatric Patient

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    Second Affiliated Hospital of Wenzhou Medical University
Updated on 5 December 2022
Accepts healthy volunteers


Anesthetic inhalation induction could be one of the most stressful experiences for children during the perioperative period, with almost 50% of them showing anxiety. It is an essential challenge for pediatric anesthesiologists on how to decrease anxiety for children in the operating room (OR) environment and to facilitate a smooth induction of anesthesia. Various factors like parental separation, unfamiliar surroundings, fear of physicians and needle injections can increase their preoperative anxiety. The researchers conducted the current study to investigate whether intranasal remimazolam can reduce anxiety in children before surgery.


children aged 2-5 years old were randomly allocated into three equal groups based on the premedication routes: Group R with intranasal remimazolam, Group D with intranasal dexmedetomidine and Group P with intranasal placebo, respectively.

Condition Sedative; Anxiety Disorder
Treatment Dexmedetomidine, Remimazolam, Distilled water for injection
Clinical Study IdentifierNCT04720963
SponsorSecond Affiliated Hospital of Wenzhou Medical University
Last Modified on5 December 2022

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