Sintilimab Plus Bevacizumab in Recurrent/Persistent Ovarian Clear Cell Carcinoma (INOVA)

  • STATUS
    Recruiting
  • End date
    Apr 30, 2024
  • participants needed
    38
  • sponsor
    Tongji Hospital
Updated on 16 May 2022

Summary

Ovarian clear cell carcinoma (OCCC) is one of the rare subtypes of ovarian cancer, yet its prognosis is extremely poor. Previous studies indicate that both bevacizumab and PD-1 inhibitor have clinical benefits for OCCC patients. And the combination of bevacizumab and PD-1 inhibitor has shown preliminary safety and clinical activity. Therefore, this study aims to investigate the potential benefit of combination therapy for patients with OCCC.

Details
Condition Ovarian Clear Cell Carcinoma
Treatment Sintilimab, Bevacizumab Biosimilar IBI305
Clinical Study IdentifierNCT04735861
SponsorTongji Hospital
Last Modified on16 May 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Female patients with age ≥ 18 years old and < 75 years old
There must be a histological diagnosis of ovarian clear cell carcinoma. For tumors with mixed histology, at least 70% of the tumors are composed of clear cell carcinoma
Patients with recurrent or persistent ovarian clear cell carcinoma must have at least one-line pretreated platinum-containing chemotherapy
Patients with recurrent or persistent ovarian clear cell carcinoma must have at least one-line pretreated platinum-containing chemotherapy
According to the definition of RECIST1.1, the patient must have measurable lesions. Measurable lesions are defined as
There is at least one lesion that can be accurately measured in at least one dimension
When measured by CT or MRI or the diameter gauge of clinical examination, each lesion must be ≥ 10 mm. When measured by chest X-ray, each lesion must be ≥ 20 mm
When lymph nodes measured by CT or MRI, the short axis of the lymph nodes must be ≥ 15 mm
It must be at least 4 weeks away from the last anti-tumor treatment before starting
the trial treatment
No administration of immune checkpoint inhibitors before
Enough archived tumor tissue blocks (or at least 10 freshly cut unstained glass slides) provided for analysis
ECOG performance status score ≤ 2
Expected survival time > 12 weeks
Adequate hematology and organ function, including
hemoglobin > 9 g/dL without blood transfusion or erythropoietin in the past 14 days
ANC ≥ 1.5×109/L without using granulocyte colony stimulating factor in the past 14 days
PLT ≥ 9×109/L without blood transfusion in the past 14 days
TBIL ≤ 1.5 ×ULN (Gilbert syndrome allows ≤ 3 × ULN)
ALT and AST ≤ 2.5 × ULN (if there is liver metastasis, ALT and AST ≤ 5 × ULN)
Serum Cr ≤ 1.5 × ULN or endogenous creatinine clearance ≥ 50 mL/min (Cockcroft-Gault formula)
Adequate coagulation function, defined as INR or PT ≤ 1.5 × ULN
Normal thyroid function is defined as TSH within the normal range. If the baseline TSH is outside the normal range, patients with total T3 (or FT3) and FT4 are within the normal range can also be included
Myocardial enzyme spectrum is within the normal range (patients with simple laboratory abnormalities judged by the investigator to be of no clinical significance are also allowed to be included)
For patients with reproductive potential, blood or urine pregnancy tests must be
negative within one week before joining the trial. If there is a risk of
pregnancy, effective contraceptive measures must be used during the entire
trial treatment until 180 days after the last administration (year failure
rate < 1%), for example: use of physical barrier contraceptive methods
(condoms) or total abstinence. Oral, injection or implantation of hormonal
contraceptives are not allowed. For women without reproductive potential
defined as
Naturally entering menopause and menopause for more than 1 year
Surgical sterilization (bilateral oophorectomy, bilateral salpingectomy or hysterectomy)
Serum follicle stimulating hormone, luteinizing hormone and plasma estradiol levels are within the menopausal standards of the research center laboratory
Patients must understand the trial process and have the ability to comply with the
trial protocol within the study period, including any treatment, examination
inspection, follow-up and questionnaire required to accomplish the trial
Patients must be willing to complete the quality of life questionnaires during the trial treatment and the follow-up, and agree that the results of these questionnaires will be used for clinical research
Any side effects of previous chemotherapy must have returned to ≤ CTCAE level 1 or baseline level, except for sensory neuropathy or alopecia with stable symptoms ≤ CTCAE level 2

Exclusion Criteria

Patients have received platelet or red blood cell transfusion within 4 weeks before the first administration
Patients receive major surgery within 4 weeks before the first administration (except for surgery for the purpose of biopsy) or expect major surgery during the study period
Severe unhealed wound ulcers or fractures
Known allogeneic organ transplantation (except for corneal transplantation) or allogeneic hematopoietic stem cell transplantation
Personnel involved in the formulation or implementation of research plans
Histological evidence of non-ovarian clear cell carcinoma
Lack of tumor samples (archived and/or recently obtained)
Previous administration of the following therapies in the past: anti-PD-1/PD-L1/PD-L2 drugs; or anti stimulating/synergistic inhibition of T cell receptor (for example, CTLA-4, CD134, CD137) drugs
Patients with contraindications of bevacizumab, including but not limited to: previous gastrointestinal perforation, receiving surgery or having incomplete-healing wound within 28 days before administration of combination therapy, severe bleeding or recent hemoptysis, and other circumstances that are inappropriate for bevacizumab according to physician's assessment
Patients are known to be allergic to the active ingredients or excipients of sintilimab or bevacizumab
Symptomatic or uncontrolled brain metastases that require simultaneous treatment, including but not limited to surgery, radiation and/or corticosteroids, or clinical manifestations of spinal cord compression
Currently participating in interventional clinical research treatment, or received other research drugs or used research equipment treatment within 4 weeks before the first administration
Diagnosis of other malignant diseases other than ovarian cancer within 5 years before the first administration (excluding radically cured skin basal cell carcinoma, skin squamous cell carcinoma, and/or radically excised carcinoma in situ)
An active autoimmune disease that requires systemic treatment (such as the use of disease-relieving drugs, glucocorticoids, or immunosuppressive agents) within 2 years before the first administration. Alternative therapies (such as thyroxine, insulin, or physiological glucocorticoids for adrenal or pituitary insufficiency) are not considered systemic treatments a
Active hemoptysis (at least 2.5ml or 1/2 teaspoon of blood was spit out at a time) within 3 months before the first administration
Patients have been vaccinated with live vaccine within 1 month before the first administrationb
Patient have received systemic treatment with anti-tumor Chinese patent medicine or immunomodulatory drugs (including thymosin, interferon, interleukin, except for local use to control pleural fluid) within 2 weeks before the first administration
Patients are receiving systemic glucocorticoid therapy (not including nasal spray, inhaled or other local glucocorticoids) or any other form of immunosuppressive therapy (including but not limited to cyclophosphamide, azathioprine, methotrexate, thalidomide and anti-TNF drugs)c
Minor surgery (outpatient or inpatient surgery requiring local anesthesia, including central venous catheterization) within 48 hours before the first administration
Use aspirin (>325 mg/day) or other non-steroidal anti-inflammatory drugs known to inhibit platelet function for 10 consecutive days at present or in the future (within 10 days before first administration)
Current or recent (within 10 days before first administration) full-dose oral or parenteral anticoagulant or thrombolytic treatment for 10 consecutive daysd
Patients have a hereditary bleeding tendency or coagulation dysfunction, or a history of thrombosis. Or the image shows tumor invasion/infiltration of large blood vessels or the researchers or radiologists assess the bleeding tendency
Clinically uncontrolled pleural effusion/abdominal effusion (patients who do not need to drain the effusion or stop drainage for 3 days without a significant increase in effusion can be included)
Known human immunodeficiency virus (HIV) infection history (HIV 1/2 antibody positive)
Untreated active hepatitis B (defined as HBsAg positive and the number of copies of HBV-DNA detected at the same time is greater than the upper limit of the normal value of the laboratory department of the research center)e
Patients who are pregnant or breastfeeding, or expect to become pregnant during the study treatment period
There is clinically unresolved toxicity from previous treatments (≥ Grade 2, except for alopecia, neuralgia, lymphopenia, and depigmentation of skin)
There are any severe or uncontrolled systemic diseases, such as
The resting electrocardiogram has major abnormalities in rhythm, conduction, or morphology that are severe and difficult to control, such as complete left bundle branch block, above II degree of heart block, ventricular arrhythmia, or atrial fibrillation
Unstable angina pectoris, congestive heart failure, chronic heart failure with NYHA grade ≥ 2
Any arterial thrombosis, embolism or ischemia, such as myocardial infarction, unstable angina, cerebrovascular accident, or transient ischemic attack within 6 months before being selected for the trial
Unsatisfactory blood pressure control (systolic blood pressure > 140 mmHg or diastolic blood pressure > 90 mmHg)
Active tuberculosis
Active or uncontrolled infection that requires systemic treatment
Clinically active diverticulitis, abdominal abscess, gastrointestinal obstruction
Liver diseases such as liver cirrhosis, decompensated liver disease, acute or chronic active hepatitis
Poor control of diabetes (FBG > 10 mmol/L)
Urine routines suggest that urine protein ≥ ++, and the 24-hour urine protein quantitative is confirmed to be > 1.0 g
Patients with mental disorders who cannot cooperate with treatment
The medical history or disease evidence, abnormal treatment or laboratory test values
that may interfere with the trial results, prevents the patients from participating in
the study. The investigator believes that there are other potential risks and the
patient is not suitable for participating in this study
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