Multi Dimensional Precise Exploration of Immunoconsolidation Therapy for Locally Advanced NSCLC After Chemo-radiotherapy

  • STATUS
    Recruiting
  • End date
    Dec 31, 2022
  • participants needed
    25
  • sponsor
    Fudan University
Updated on 15 February 2021

Summary

The purpose of this study is to carry out a prospective observational study in patients with locally advanced NSCLC receiving radical concurrent chemoradiotherapy and follow-up immune consolidation therapy. By detecting ctDNA and TILs of the patients, we explored the value of blood dynamic monitoring of ctDNA in patients with prognosis stratification and treatment effect, and explored the patients before and after concurrent chemoradiotherapy and immune consolidation therapy The characteristics of DNA, RNA, T cells and other biomarkers were correlated with the efficacy and prognosis.

Details
Condition Non-Small Cell Lung Cancer, Chemotherapy, Chemotherapy, Chemoradiation, Chemoradiotherapy, ctDNA, nsclc
Clinical Study IdentifierNCT04741633
SponsorFudan University
Last Modified on15 February 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Non small cell lung cancer patients confirmed by pathology
They were 18-80 years old
The tumor could not be resected or could not tolerate surgery
Planed to receive chemoradiotherapy and subsequent immunoconsolidation therapy
Clinical stage III (AJCC, 8th Edition, 2017)
After systematic detection of non-small cell lung cancer core indicators including EGFR, ALK, ros1, KRAS, ntrk, TMB, etc
Patient informed consent

Exclusion Criteria

After radiotherapy and chemotherapy, the disease progressed and immune maintenance therapy could not be carried out
It can not cooperate with the completion of baseline mutation screening and subsequent sample detection
Factors judged by other researchers not suitable for further study
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