Impact of Remimazolam on Prognosis After Bladder Cancer Surgery

  • STATUS
    Recruiting
  • End date
    Oct 19, 2023
  • participants needed
    1128
  • sponsor
    Peking University First Hospital
Updated on 19 July 2021
invasive bladder cancer
transurethral resection
bladder tumor
transurethral bladder excision
surgery for bladder cancer

Summary

Bladder cancer is one of the most common genitourinary cancers. Transurethral resection of bladder tumor (TURBT) is the standard therapy for nonmuscle invasive bladder cancer. However, patients after TURBT are at risk for recurrence and progression. Benzodiazepines are proved to inhibit proliferation of multiple types of cancer cells in vitro. Delirium is an acute onset and transient cerebral dysfunction and is associated with worse outcomes. Previous studies indicated that benzodiazepines increase incidence of postoperative delirium. Remimazolam is a new benzodiazepine with rapid onset and ultra-short activity. The aims of this study are to explore the impact of remimazolam for general anesthesia on emergency delirium and recurrence-free survival in patients undergoing bladder cancer surgery.

Description

Bladder cancer is one of the most common genitourinary cancers. Approximately 70-80% of bladder cancers are nonmuscle invasive, including those of Ta-T1 stage and carcinoma in situ. Transurethral resection of bladder tumor (TURBT) is the standard therapy for nonmuscle invasive bladder cancer. However, patients after TURBT are at a high risk of recurrence and progression.

Recently, impacts of anesthetic agents on tumor cells have attracted more attention. Benzodiazepines are found to inhibit proliferation of lymphoma, neural tumor, lung cancer, rectal cancer and breast cancer cells in vitro. Midazolam may have anti-tumor effects through induction of apoptosis and inhibition of inflammatory reaction. However, clinical evidence regarding effects of benzodiazepines on outcomes after cancer surgery remains lacking.

Remimazolam is a new benzodiazepine with rapid onset and ultra-short activity. It is rapidly metabolized by tissue esterases to inactive metabolite and can be reversed by flumazenil. Therefore, patients wake up rapidly even after prolonged infusions. It is also found to produce less respiratory and circulatory depression when compared with propofol.

Delirium is an acute onset and transient cerebral dysfunction, and is associated with worse outcomes including prolonged hospitalization, worse functional recovery, cognitive decline, and increased mortality rate. Previous studies indicated that benzodiazepines increase incidence of postoperative delirium, possibly due to prolonged action. With the property of ultra-short activity, remimazolam may not increase the incidence of delirium. But evidence is lacking in this aspect.

The aims of this study are to explore the impact of remimazolam on emergency delirium and recurrence-free survival in patients undergoing bladder cancer surgery.

Details
Condition Surgery, Delirium, urinary tract neoplasm, bladder cancer, bladder disorder, Surgical aspects, Surgery, Benzodiazepines, Urothelial Cancer, Bladder Disorders, Bladder Carcinoma, Urologic Cancer, Cancer Recurrence, benzodiazepine, carcinoma of the bladder, bladder tumor, surgical procedures, surgical treatment, surgeries, surgical procedure
Treatment Propofol, Remimazolam
Clinical Study IdentifierNCT04532606
SponsorPeking University First Hospital
Last Modified on19 July 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Age 50 years and <90 years
Preoperative diagnosis is non-muscle-invasive bladder cancer(Ta-T1)
Scheduled to undergo transurethral resection of bladder tumor
Agree to participate, and provide written informed consent

Exclusion Criteria

Refuse to participate
Emergent surgery
Use of benzodiazepines for 1 week within the last month before surgery
Combined with other malignant tumors
Preoperative history of schizophrenia, epilepsy, parkinsonism or myasthenia gravis
Inability to communicate in the preoperative period due to coma, profound dementia, language barrier, or end-stage disease
Critical illness (preoperative American Society of Anesthesiologists physical status classification IV), severe hepatic dysfunction (Child-Pugh class C), or severe renal dysfunction (undergoing dialysis before surgery)
The purpose of surgery is to make a diagnosis or preoperative judgement is that tumor cannot be completely removed
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