Neuro-ultrasound Assessment in Behcet's Disease

  • End date
    Aug 14, 2021
  • participants needed
  • sponsor
    Assiut University
Updated on 14 February 2021


Assessment of structural changes that occur in large extracranial and intracranial arteries in patients with Behcet's disease


Patients will be selected from Rheumatology and Rehabilitation inpatient and outpatient clinics in Assiute University Hospital Patients under 16 years old, patients with hyperlipidemia, hypertension, diabetes mellitus and all other risk factors affecting blood vessel intimal thickness will be excluded from the research.

All patients and control groups underwent a complete extracranial and intracranial ultrasound assessment by 2 experienced neurovascular sonographers .The ultrasound examination was done at the Neurovascular Ultrasound Laboratory in the Neurology department, Assiut University hospitals using a color-coded duplex ultrasound device Philips HD5 (Philips Medical Systems, Nederland B.V.) for the carotid and vertebral arteries and for the intracranial arteries.

Intimal medial thickness (IMT) of the common carotid artery (CCA), peak systolic velocities (PSVs) and end diastolic velocities (EDVs) were measured in the common, internal, and external carotid arteries (CCA, ICA, ECA) with L 3-12 MHz linear transducer probe and when stenosis was detected the velocities were measured at the maximally stenotic area.

The intracranial arteries were evaluated in all patients with transcranial color-coded duplexsonography (TCCS) with the use of a low-frequency (2- to 5-MHz) phased-array probe through the transtemporal acoustic bone window. The middle cerebral artery (MCA), intracranial segment of vertebral artery (V4)and basilar artery (BA) were examined. Peak systolic velocity (PSV) and flow direction (antegrade or reversed) used for the diagnosis of any intracranial atherosclerotic disease (ICAD).

The findings and the atherosclerotic changes in the extracranial and intracranial vessels were interpreted according to the internationally published data Data will be analyzed using the computer program SPSS

Condition Behcet's Syndrome, Anterior uveitis, behcet's disease
Treatment ultrasound
Clinical Study IdentifierNCT04738864
SponsorAssiut University
Last Modified on14 February 2021


Yes No Not Sure

Inclusion Criteria

Gender: Male or Female
Do you have any of these conditions: behcet's disease or Anterior uveitis or Behcet's Syndrome?
patient more than 18 years old
All patients fulfill the modified International Criteria for Behet's Disease

Exclusion Criteria

Patients under 16 years old
patients with hyperlipidemia, hypertension, diabetes mellitus and all other risk factors affecting blood vessel intimal thickness
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