Azithromycin for Meibomian Gland Disease
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- STATUS
- Recruiting
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- End date
- Dec 1, 2023
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- participants needed
- 40
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- sponsor
- University of California, San Francisco
Summary
This study aims to elucidate the effectiveness of oral azithromycin in treating symptomatic dry eye syndrome secondary to Meibomian gland dysfunction.
Description
This is a randomized, placebo-controlled, double masked trial of the effectiveness of oral azithromycin in treating symptomatic dry eye syndrome secondary to Meibomian gland dysfunction. Dry eye syndrome (DES) is a persistent feeling of ocular discomfort that encompasses dryness, irritation, foreign body sensation and burning. In the United States, it is the most common non-refractive cause of visits to eye care providers, and has been shown to have a significant impact on quality of life of patients who suffer from this condition. most common cause of DES is Meibomian gland disease (MGD). In the vast majority of cases, MGD is not binding, but rather causes persistant ocular discomfort.
Oral antibiotics, particularly the tetracyclines and macrolides, are frequently prescribed for the treatment of MGD. There is little good-quality evidence to support this practice. This study is designed to evaluate the effectiveness of oral azithromycin on patient-reported dry eye symptoms. Concomitantly, we will also study the composition of the ocular surface microbiome in MGD, and its response for oral antibiotics.
Details
| Condition | Dry eye syndrome, Keratoconjunctivitis Sicca, Dry Eyes, anxiety/depression, eye dryness, dry eye, Neuropathic Eye Pain, Ocular Microbiome |
|---|---|
| Treatment | Azithromycin Oral Product, Placebo Oral |
| Clinical Study Identifier | NCT03953118 |
| Sponsor | University of California, San Francisco |
| Last Modified on | 13 February 2021 |
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