Evaluation of Association Between Testosterone Levels, Dementia, and Adverse Mental Health Outcomes

  • STATUS
    Recruiting
  • participants needed
    700000
  • sponsor
    M.D. Anderson Cancer Center
Updated on 30 November 2022
anxiety
depressed mood
Accepts healthy volunteers

Summary

This study evaluates the association between testosterone levels and risk of dementia and adverse mental health outcomes (e.g. depression and anxiety). It is not known whether low testosterone levels may be associated with an increased risk of dementia. Learning about the association between testosterone levels and risk of dementia may help determine the long-term effects of androgen deprivation therapy and may help improve quality of life.

Description

PRIMARY OBJECTIVE:

I. To use a Mendelian randomization study design to determine whether genetically predicted decreased testosterone levels are associated with an increased risk of dementia.

SECONDARY OBJECTIVE:

I. To examine whether genetically predicted decreased testosterone levels are associated with worse cognitive function and adverse mental health outcomes.

OUTLINE

Patients' records from institutional or national biobanks are reviewed.

Details
Condition Anxiety Disorder, Depression, Genetic Disorder, Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Treatment Electronic Health Record Review
Clinical Study IdentifierNCT04743466
SponsorM.D. Anderson Cancer Center
Last Modified on30 November 2022

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