Precision Targeting of Propofol-induced Electroencephalographic Slow Waves: a Novel Phase I/2 Paradigm for Treatment-resistant Major Depressive Disorder
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- STATUS
- Recruiting
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- End date
- Dec 1, 2026
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- participants needed
- 85
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- sponsor
- Washington University School of Medicine
Summary
Our overall hypothesis is that sleep slow-wave potentiation by propofol is a therapeutic pathway for enhancing slow wave sleep and alleviating treatment-resistant depression (TRD).
Description
Aim 1: Establish the safety and feasibility of multiple propofol infusions targeting of electroencephalographic (EEG) slow-wave activity (SWA) without burst suppression in geriatric patients with treatment-resistant depression (TRD) patients.
Aim 2: Compare sleep EEG SWA in geriatric patients with treatment-resistant depression (TRD) patients randomized to two arms: 1) multiple moderate-dose propofol infusions targeting of unconsciousness and electroencephalographic (EEG) slow-wave activity (SWA) without burst suppression vs 2) multiple low-dose propofol infusions targeting unconsciousness with minimal electroencephalographic (EEG) slow-wave activity (SWA) or burst suppression.
Details
| Condition | Treatment Resistant Depression |
|---|---|
| Treatment | Propofol, Electroencephalography (EEG), Electroencephalographic (EEG), Phase I: Propofol infusion - moderate dose, Slow-Wave Activity |
| Clinical Study Identifier | NCT04680910 |
| Sponsor | Washington University School of Medicine |
| Last Modified on | 14 October 2022 |
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