Reducing Post-traumatic Stress Disorder After ICU Discharge With the IPREA3 Program

  • STATUS
    Recruiting
  • End date
    Jan 1, 2022
  • participants needed
    4500
  • sponsor
    Centre Hospitalier of Chartres
Updated on 12 February 2021

Summary

Reducing discomfort in the intensive care unit (ICU) should be beneficial to longterm outcomes. This study assesses whether a tailored multicomponent program for discomfort reduction may be effective in reducing post-traumatic stress disorder (PTSD) symptoms at 1-year in general ICU survivors.

Description

After carrying out the cluster-randomized controlled IPREA3 study demonstrating that a tailored multicomponent program based on assessment of self-perceived discomfort, feedback to the healthcare teams, and tailored site-targeted measures was effective to decrease self-perceived overall discomfort, we performed the 1-year follow-up of ICUs survivors included in the IPREA3 study to assess psychiatric morbidity at 1 year. Our tailored multicomponent program was also associated with less PTSD at 1 year. Based on this positive long-term result, this study confirms the need to implement a new strategy for reducing discomfort in the ICU based on such programs.

PTSD-REA is a stepped wedge cluster randomized trial involving 18 ICUs. The exposure will be the implementation of a tailored multicomponent program consisting of assessment of ICU-related self-perceived discomforts, immediate and monthly feedback to the healthcare team, and site-specific tailored interventions. The eligible patients will be exposed vs. unexposed general adult ICU survivors. The prevalence of substantial posttraumatic stress disorder (PTSD) symptoms at 1 year will be assessed by using diagnostic criteria adapted to the new definition of PTSD according to DSM-5.

Details
Condition Critical Illness, critically ill
Treatment Administration of the IPREA3 questionnaire, Immediate feedback through electronic reminder messages, Targeted interventions in each ICU to reduce discomforts
Clinical Study IdentifierNCT03991611
SponsorCentre Hospitalier of Chartres
Last Modified on12 February 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Is your age greater than or equal to 18 yrs?
Gender: Male or Female
Do you have any of these conditions: critically ill or Critical Illness?
Patients who survived an ICU stay of at least 3 calendar days
Affiliation to a social security scheme

Exclusion Criteria

Deceased during the ICU stay
Minors
Under trusteeship
Without affiliation to a social security scheme
Transferred to another ICU
Transferred from another ICU
Already included in the study
Limitation and cessation of active treatment
Advance healthcare directive indicating the refusal of ICU stay
Irreversible state like diminished cognitive capacity based on the investigator's opinion or not understanding French sufficiently to be questioned (language barrier)
Subject not consenting to participate in the study
Clear my responses

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