A Post-treatment Program to Identify and Manage Complications Related to Oncology or Hematology Treatments in Cancer Survivors.
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- STATUS
- Recruiting
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- End date
- Apr 24, 2028
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- participants needed
- 858
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- sponsor
- Centre Leon Berard
Summary
INTRODUCTION: Approximately 44% of cancer survivors experience a deteriorated quality of life 5 years after diagnosis due to late onset of complications related to cancer treatments. The objective of the study is to evaluate the incidence rates of treatment-related complications, identify sub-clinical abnormalities and risk factors in patients participating in the PASCA post-treatment program.
METHOD: PASCA is a single-center, interventional cohort study of adult patients who received at least chemotherapy and with a complete remission to a testicular germ cell tumor, primary non-metastatic invasive breast carcinoma, high-grade soft tissue sarcoma, osteosarcoma, Ewing's sarcoma, acute myeloid leukemia, Hodgkin's or aggressive non-Hodgkin's lymphoma. Four assessment visits will be scheduled at 1 month (T1), 6 months (T2), 24 months (T3) and 60 months (T4) after completion of treatment. During these visits, 22 complications will be screened and follow-up care will be systematically offered to the health professional concerned by the complication in case of a positive result. The screening will contain the following elements: screening self-questionnaires, quality of life questionnaire, 12 biological parameters, a urinalysis evaluating hematuria, proteinuria, and leukocyturia, a spirometry, an electrocardiogram, 5 tests evaluating physical condition, vital signs and the perimetric measurement between both arms.
DISCUSSION: This systematic screening could highlight a number of complications occurring after cancer treatments. Sub-clinical abnormalities and new risk factors could also be identified. This new organization of care could improve the quality of life of adult cancer survivors.
Details
| Condition | Hodgkin's Disease, Hodgkin's Disease, Lymphoma, Non-Hodgkin's Lymphoma, Ewing's sarcoma, Osteosarcoma, Osteosarcoma, Acute myeloid leukemia, Acute Myelogenous Leukemia (AML), Acute myeloid leukemia, Lymphoma, Sarcoma, Sarcoma, Sarcoma (Pediatric), Soft Tissue Sarcoma, Non-Hodgkin's Lymphoma, Acute Myelogenous Leukemia (AML), Late Effects, Sarcoma (Pediatric), Soft Tissue Sarcoma, Late Effect, non-hodgkin's lymphoma (nhl), bone sarcoma, hodgkin, hodgkin's lymphomas, hodgkin lymphomas, hodgkins lymphoma, hodgkin's lymphoma, acute myelogenous leukemia, anll, acute myeloblastic leukemia, Testicular Germ Cell Tumor Mixed, Non-Metastatic Breast Carcinoma, Soft Tissue Sarcoma, Adult, Stage IIC, Non-Metastatic Breast Carcinoma, Soft Tissue Sarcoma, Adult, Stage IIC |
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| Treatment | PASCA intervention |
| Clinical Study Identifier | NCT04671693 |
| Sponsor | Centre Leon Berard |
| Last Modified on | 16 February 2021 |
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