Evaluation of Peripheral Itch Mechanisms Following Injection of Morphine (Second Sub-Project)

  • STATUS
    Recruiting
  • End date
    Dec 31, 2022
  • participants needed
    26
  • sponsor
    Aalborg University
Updated on 12 February 2021

Summary

The aim of our 2nd sub-project is to clarify if the capsaicin receptor TRPV1 is implicated in the mechanism of morphine-induced mast cell degranulation. Moreover, we also aim to clarify if the mechanism of opioid-induced itch relay on the histaminergic pathway by using the antihistamine (diphenhydramine) to suppress the release of histamine from peripheral mast cells.

Details
Condition Pruritus
Treatment Capsaicin, Diphenhydramine, Isotonic saline, histamine, Morphine Chloride
Clinical Study IdentifierNCT04700007
SponsorAalborg University
Last Modified on12 February 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Is your age between 18 yrs and 60 yrs?
Gender: Male or Female
Do you have any of these conditions: Do you have Pruritus??
Healthy men and women
-60 years
Speak and understand English

Exclusion Criteria

Participants with any clinically significant abnormalities that in the opinion of the investigator may increase the risk associated with trial participation or may interfere with the interpretation of the trial results
Pregnancy or lactation
Drug addiction defined as any use of cannabis, opioids or other addictive drugs
Lack of ability to cooperate
Current use of medications that may affect the trial such as antihistamines, antipsychotics and pain killers as well as systemic or topical steroids
Participants with known allergy/discomfort to the opioid morphine and antihistamine
Skin diseases
Moles, scars or tattoos in the area to be treated or tested
Consumption of alcohol or painkillers 24 hours before the study days and between these
Acute or chronic pain
Participation in other trials within 1 week of study entry (4 weeks in the case of pharmaceutical trials)
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