Multimodal Spectroscopy to Detect Urothelial Cancer in Urine

  • STATUS
    Recruiting
  • End date
    Jan 25, 2024
  • participants needed
    500
  • sponsor
    University of Florence
Updated on 24 May 2022
cancer
urine cytology
urinary tract cancer

Summary

To facilitate the follow-up of urothelial tumors and also make them more tolerable and less invasive for patients, there is a minimally invasive and easy to perform examination which is urinary cytology on 3 samples. This test is extremely specific, over 90% chance of cancer if it is positive and is performed by expert cytopathologists, but it is burdened by a very low sensitivity, which is especially acute in the case of low grade tumors. This makes it an extremely useful test in case of positivity, but of little use if negative or doubtful, not being able to consider it reliable.

To overcome this problem, our study aims to bring an approach based on a physical principle, that is spectroscopy, which is fast non-invasive and does not require the use of additional substances or contrast media in the diagnosis of urothelial neoplasms in samples of urine.

In our experience, multimodal optical fiber spectroscopy has proved extremely valid in discriminating healthy urothelial tissue from tumor ex vivo, as well as providing important information on the degree of urothelial neoplasia, with accuracy rates higher than 80%, for which developed the idea of a technique based on multimodal spectroscopy.

If our method proves valid, it could improve the follow up and management of patients with urothelial cancer, being able to support normal cytology and provide further support to the cytopathologist, as well as simplify the diagnosis.

Details
Condition Urothelial Carcinoma, Urinary Bladder Cancer, Urinary Tract Cancer
Treatment Surgery, Urinary Multimodal Fiber Optic Spectroscopy, Urine Cytology, Urine Cytology
Clinical Study IdentifierNCT04718948
SponsorUniversity of Florence
Last Modified on24 May 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients over the age of 18 who are known for urological interventions for the following
pathologies will be considered for enrollment in the control group
Kidney, ureteral or bladder stones
BPH

Exclusion Criteria

Age under 18
Pregnancy
Lack of informed consent
Indwelling Catheter wearers
Presence of prostate cancer
Presence of kidney cancer, including kidney pelvic tumors
Presence and / or history of ureteral cancer
Presence and / or history of bladder cancer
Presence and / or history of urethral cancer
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