Hemodynamic Effect of Norepinephrine Versus Vasopressin on the Pulmonary Circulation in Cardiac Surgery Patients:

  • STATUS
    Recruiting
  • days left to enroll
    78
  • participants needed
    150
  • sponsor
    The Cleveland Clinic
Updated on 20 October 2021

Summary

The relative increase in the mPAP with the same unit increase in MAP adjusted for baseline, and RV function assessed by GLS, between VP and NE in patients with normal and increased pulmonary artery pressure, who require vasopressor support during cardiac surgery.

Description

The specific aims of our study are to compare 1) the relative increase in the mPAP with the same unit increase in MAP adjusted for baseline and 2) RV function assessed by GLS, between VP and NE in patients with normal and increased pulmonary artery pressure, who require vasopressor support during cardiac surgery. We hypothesize that the use of vasopressin compared with norepinephrine induces a lower mPAP-to-MAP ratio, in cardiac surgical patients with and without pulmonary hypertension who require intraoperative vasopressor support. Second, we will test the hypothesis that vasopressin is associated with improved right ventricular global longitudinal strain compared to norepinephrine in patients requiring vasopressor support during cardiac surgery.

Details
Condition cardiac disorders, Cardiac Disease, heart diseases, cardiac diseases, Heart disease, Cardiovascular Disease, cardiac disorder, Heart Disease, heart disorder
Treatment Vasopressin, Norepinephrine
Clinical Study IdentifierNCT04501861
SponsorThe Cleveland Clinic
Last Modified on20 October 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Adults> 18 years of age
Elective cardiac surgery with the use of CPB
Patients with pulmonary artery catheter insertion
Systemic hypotension (MAP < 70 mmHg) requiring continuous infusion of vasopressor

Exclusion Criteria

Transplant surgery
Ventricular assist device implantation other than intra-aortic balloon counter-pulsation
Pulmonary endarterectomy
Thoracoabdominal aneurysm repair
Inhalational pulmonary vasodilators (e.g. Epoprostenol) administration before insertion of pulmonary artery catheter
Vasopressin is started as the first choice of pressor per clinical staff discretion
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