HB10101 Multiple Myeloma
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- STATUS
- Recruiting
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- End date
- Jan 3, 2026
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- participants needed
- 48
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- sponsor
- Hadassah Medical Organization
Summary
It is a phase one study with dose escalation and safety CART in BCMA- Expressing Multiple Myeloma Patients
Description
The intention with HBI0101 CART is to follow the chimeric antigen receptor T-cells (CART) approach, as for approved products, but target the B cell maturation antigen (BCMA) rather than the CD19 antigen targeted by KYMRIAHTM (tisagenlecleucel) and YESCARTATM (axicabtagene ciloleucel).
Importantly, successful results from at least three clinical trials of a BCMA targeted CAR T therapy were published (Zhao 2018, Brundo 2018, Raje 2019), with excellent results obtained for relapsed or refractory multiple myeloma (MM) patients, that validate the approach. The CAR vector employed for HBI0101 CART is almost identical to the vector employed for the clinical study reported by Raje 2019, therefore, a strong therapeutic response is expected also for HBI0101 CART together with a similar manageable safety profile
Details
| Condition | Dose Escalation and Safety |
|---|---|
| Treatment | CART BCMA |
| Clinical Study Identifier | NCT04720313 |
| Sponsor | Hadassah Medical Organization |
| Last Modified on | 3 February 2021 |
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