The Effectiveness and Safety of Resective Epilepsy Surgery for TRE

  • STATUS
    Recruiting
  • End date
    Feb 1, 2024
  • participants needed
    200
  • sponsor
    Beijing Children's Hospital
Updated on 3 February 2021

Summary

Prospective controlled studies to identify clinical epilepsy control, cognitive changes, and safety in resective epilepsy surgery of tuberculosis-related epilepsy.

Description

Control group: clear epilepsy focus in the brain, and medication has been continued.

Surgery group: clear epilepsy focus in the brain, and resective epilepsy surgery for tuberculosis-related epilepsy.

In order to ensure the follow-up of the study and 3 years after the end of the study, 100 cases were collected from each group of the study.

Details
Condition Tuberous Sclerosis, Epilepsy, Epilepsy, Seizure Disorders, Seizure Disorders (Pediatric), Hereditary Neoplastic Syndrome, Hereditary Cancer Syndromes, Seizure Disorders (Pediatric), Seizure Disorders, Hereditary Cancer Syndromes, epileptic, seizure disorder, epilepsia, epileptics, pringle, sclerosis, cerebral, bourneville's disease
Clinical Study IdentifierNCT04198181
SponsorBeijing Children's Hospital
Last Modified on3 February 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

years old and above, no gender restriction, TSC gene monitoring with or without abnormality
Diagnosis of nodular sclerosis and epilepsy
Epilepsy course for more than 1 year
Patients who have taken 3 or more reasonable choices with appropriate and tolerable antiepileptic drugs (excluding mTOR inhibitors and traditional Chinese medicine and prescriptions) had seizures more than 12 times in the 3 months before enrollment
The family members agreed to enroll and signed the informed consent

Exclusion Criteria

Obvious renal angiomyolipoma, pulmonary lymphoma leiomyomatosis, and subventricular giant cell astrocytoma
Abnormal heart, lung, liver, and kidney functions and coagulation function
The family did not sign the informed consent
Preoperative evaluation, it is considered that no surgical treatment is needed
The patient received other craniocerebral surgical treatment within 1 year during the follow-up period
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