HIV Switch Trial in Experienced Patients With Multiple Class Resistance Including NNRTI Resistance

  • participants needed
  • sponsor
    Clinique du Quartier Latin
Updated on 7 December 2022


This is a pilot, open, prospective, non-randomized study to evaluate the safety and efficacy of switches from etravirine to doravirine, in experienced patients with multiple class resistance including NNRTI resistance. The other ARV medication (protease inhibitor, entry inhibitor and integrase inhibitor) that some patients receive, in addition to the NRTI and NNRTI, will not be changed.

The study will be performed only on two sites


The duration of the study will be of 120 weeks: 24 for recruitment and 96 weeks of follow-up. The reasons for the study duration of 2 years is that, up to now, doravirine has not been studied in 2 or 3 classes multi-drug-resistance (MDR) and thus, demonstration of durability of effect over a prolonged period of time is as important as the short-term efficacy.

Condition HIV infection, HIV Infections, Immunodeficiency, Primary Immunodeficiency Disorders, Primary Immunodeficiency Disorders, HIV Infections, human immunodeficiency virus, hiv disease
Treatment Doravirine
Clinical Study IdentifierNCT04334551
SponsorClinique du Quartier Latin
Last Modified on7 December 2022

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