Acute Heart Failure With Preserved Ejection Fraction - COngestion Discharge Evaluation

  • End date
    Aug 29, 2026
  • participants needed
  • sponsor
    Central Hospital, Nancy, France
Updated on 2 February 2021


The AHF-CODE preserved study is a prospective, non-randomized, monocenter study performed in patients with heart failure with preserved ejection fraction admitted for worsening heart failure.

The main objective of the AHF-CODE preserved study is to identify congestion markers (clinical, biological and ultrasound) at the end of hospitalization for acute heart failure that are associated with the risk of all cause death or rehospitalization for acute heart failure within 3 months of hospital discharge.

Condition Acute Heart Failure
Treatment Telephone interview, Clinical examination centered on congestion, Biological: Blood sample retrieved for biological assessment and biobanking, Cardio-pulmonary, peritoneal, jugular and renal venous Doppler ultrasounds
Clinical Study IdentifierNCT04343430
SponsorCentral Hospital, Nancy, France
Last Modified on2 February 2021


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Inclusion Criteria

Patients hospitalised for acute heart failure
Patient with preserved ejection fraction (FE 50%)
Patients considered clinically discharging from hospitalisation for acute heart failure
Age 18 years
Patients having received complete information regarding the study design and having signed their informed consent form
Patient affiliated to or beneficiary of a social security scheme

Exclusion Criteria

Comorbidity for which the life expectancy is 3 months
Dialysis patient (peritoneal dialysis or hemodialysis) or patients with glomerular filtration rate <15 ml/min/m at inclusion
History of lobectomy or pneumonectomy lung surgery
Severe pulmonary or pleural pathology preventing reliable acquisition of lung ultrasound images: severe emphysema, chronic pleurisy, pulmonary fibrosis, etc
Valvulopathy causing decompensation of heart failure for which intervention is being considered
Pregnant woman, parturient or nursing mother
Adult person subject to a legal protection measure (guardianship, curatorship, safeguard of justice)
Adult person who is unable to give consent
Person deprived of liberty by a judicial or administrative decision
Person subject to psychiatric care pursuant to Articles L. 3212-1 and L. 3213-1 of the Public Health Code
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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