PET-imaging of Unruptured Intracranial Aneurysm Inflammation

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    Turku University Hospital
Updated on 2 February 2021


The main purpose of this study is to determine if PET-imaging can be used to evaluate inflammation level of intracranial aneurysms, thus helping to evaluate the rupture risk of intracranial aneurysm.


Study subjects are patients who are diagnosed with an unruptured saccular intracranial aneurysm and planned for elective surgical treatment of intracranial aneurysms. Prior the planned surgery, all study subjects will undergo PET-imaging of the brain with 18F-FDG- and 68Ga-DOTANOC-tracers targeting glucose metabolism and somatostatin receptors in inflammatory cells. After PET-imaging, samples for histopathological examination from the intracranial aneurysm sac will be collected during the surgery from every study subject. Blood samples are collected prior to aneurysm operation from the routine pre-operative laboratory tests. Cerebrospinal fluid samples are collected during the surgical procedure from the surgical site. From blood samples we will evaluate expression of 20 different circulating microRNAs (miRNA) and the level of tumor necrosis factor-1, interleukin 1 beta, vascular endothelial growth factor, and evaluate correlations between miRNA expression and SUVmax in PET-imaging and miRNA and aneurysm histological findings.

Correlation between inflammatory findings in histological studies and PET-imaging will be evaluated (correlation of SUVmax to aneurysm histological findings).

Condition Inflammation, Inflammation, Berry Aneurysm, Aneurysm, Aneurysm, cerebral aneurysm, intracranial aneurysm, cerebral aneurysms
Treatment PET imaging, 18F-FDG, PET imaging, 68Ga-DOTANOC
Clinical Study IdentifierNCT04715503
SponsorTurku University Hospital
Last Modified on2 February 2021


Yes No Not Sure

Inclusion Criteria

Fusiform intracranial aneurysms
Following medications: Asetylsalisylic acid or non-steroidal anti-inflammatory drugs
Patients who have contraindication for magnetic resonance imaging (Pace Makers, foreign ferromagnetic bodies or implants)
Patients who are allergic to contrast agents
Underage persons
Patients on somatostatin analogue medication or with known neuroendocrine tumor

Exclusion Criteria

Patients who are diagnosed with unruptured intracranial aneurysm with MRI/MRA or DSA
Patients who are planned to undergo surgical treatment (ligation) of the intracranial aneurysm
Age 18 and <75 years
Saccular intracranial aneurysm with maximum diameter 3 mm
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